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Substance Name: Dextran 70 [USAN]
RN: 9004-54-0

Note

  • A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Anticoagulants
  • Blood Flow Adjuvant
  • Blood Substitutes
  • Drug / Therapeutic Agent
  • Hematologic Agents
  • Human Data
  • Plasma Substitutes
  • Plasma Volume Extender
  • Reproductive Effect
  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
  • Tumor Data

Names and Synonyms

Results Name

  • Dextran 70 [USAN]

Name of Substance

  • Dextran
  • Dextran 40 [USAN:USP]
  • Dextran 70 [USAN]
  • Dextrans

MeSH Heading

  • Dextrans

Synonyms

  • Aquasite
  • CCRIS 2469
  • Dextran
  • Dextran 40
  • Dextran 40,70,110
  • Dextran 70
  • Dextrano
  • Dextrano [INN-Spanish]
  • Dextrans
  • Dextranum
  • Dextranum 40,70
  • Dextranum [INN-Latin]
  • EINECS 232-677-5
  • Eudextran
  • Gentran 40
  • LMD
  • LMWD
  • Lomodex 40
  • Low molecular dextran-L
  • LVD
  • Macrodex
  • Polyglucinum
  • Rheomacrodex
  • Rheopolyglucine
  • UNII-05Q25F6XJ3
  • UNII-21C3YS80Q6
  • UNII-41Z0077J45
  • UNII-42N66Q2197
  • UNII-65DL069QBP
  • UNII-7C8S056150
  • UNII-7SA290YK68
  • UNII-B854H05S7D
  • UNII-E8A73H7RG1
  • UNII-EW7Q6SVD0D
  • UNII-K3R6ZDH4DU
  • UNII-P8272ET3N5
  • UNII-PD6VU01UVN
  • UNII-V7031C06AY
  • UNII-ZNJ8R24I7Z

Systematic Names

  • Dextran
  • Dextran 1
  • Dextran 10
  • Dextran 11
  • Dextran 2
  • Dextran 40
  • Dextran 5
  • Dextran 70
  • Dextrans
  • Polyglusol

Superlist Name

  • Dextran

Registry Numbers

CAS Registry Number

  • 9004-54-0

FDA UNIIs

  • 05Q25F6XJ3
  • 21C3YS80Q6
  • 41Z0077J45
  • 42N66Q2197
  • 65DL069QBP
  • 7C8S056150
  • 7SA290YK68
  • B854H05S7D
  • E8A73H7RG1
  • EW7Q6SVD0D
  • K3R6ZDH4DU
  • P8272ET3N5
  • PD6VU01UVN
  • V7031C06AY
  • ZNJ8R24I7Z

Other Registry Numbers

  • 11104-36-2
  • 11121-03-2
  • 12626-85-6
  • 128635-03-0
  • 1307300-43-1
  • 37224-17-2
  • 60454-72-0
  • 86280-85-5
  • 9013-80-3
  • 9044-66-0
  • 911319-01-2

System Generated Number

  • 0009004540

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 unreported 13500mg/kg (13500mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gematologiya i Transfuziologiya. Hematology and Transfusion Science. Vol. 31(10), Pg. 38, 1986.
mouse LD50 intravenous 12100mg/kg (12100mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.
mouse LD50 oral > 12gm/kg (12000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.
mouse LD50 subcutaneous 13900mg/kg (13900mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.
rabbit LD50 intravenous 17400mg/kg (17400mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.
rabbit LD50 intravenous 208gm/kg (208000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 201, 1975.
rat LD50 intravenous 6900mg/kg (6900mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.
rat LD50 oral > 3gm/kg (3000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.
rat LD50 subcutaneous 10700mg/kg (10700mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.
women TDLo intravenous 6mg/kg (6mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

VASCULAR: OTHER CHANGES

CARDIAC: OTHER CHANGES
British Medical Journal. Vol. 2, Pg. 1502, 1976.