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Substance Name: Dextran 70 [USAN]
RN: 9004-54-0
Note
- A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.
Molecular Formula
- Unspecified
Molecular Weight
- 180.1559
Classification Codes
- Anticoagulants
- Blood Flow Adjuvant
- Blood Substitutes
- Drug / Therapeutic Agent
- Hematologic Agents
- Human Data
- Plasma Substitutes
- Plasma Volume Extender
- Reproductive Effect
- TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
- Tumor Data
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Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Names and Synonyms
Results Name
- Dextran 70 [USAN]
Name of Substance
- Dextran
- Dextran 40 [USAN:USP]
- Dextran 70 [USAN]
- Dextrans
MeSH Heading
- Dextrans
Synonyms
- Aquasite
- CCRIS 2469
- Dextran
- Dextran 40
- Dextran 40,70,110
- Dextran 70
- Dextrano
- Dextrano [INN-Spanish]
- Dextrans
- Dextranum
- Dextranum 40,70
- Dextranum [INN-Latin]
- EINECS 232-677-5
- Eudextran
- Gentran 40
- LMD
- LMWD
- Lomodex 40
- Low molecular dextran-L
- LVD
- Macrodex
- Polyglucinum
- Rheomacrodex
- Rheopolyglucine
- UNII-05Q25F6XJ3
- UNII-21C3YS80Q6
- UNII-41Z0077J45
- UNII-42N66Q2197
- UNII-65DL069QBP
- UNII-7C8S056150
- UNII-7SA290YK68
- UNII-B854H05S7D
- UNII-E8A73H7RG1
- UNII-EW7Q6SVD0D
- UNII-K3R6ZDH4DU
- UNII-P8272ET3N5
- UNII-PD6VU01UVN
- UNII-V7031C06AY
- UNII-ZNJ8R24I7Z
Systematic Names
- Dextran
- Dextran 1
- Dextran 10
- Dextran 11
- Dextran 2
- Dextran 40
- Dextran 5
- Dextran 70
- Dextrans
- Polyglusol
Superlist Name
- Dextran
Registry Numbers
CAS Registry Number
- 9004-54-0
FDA UNIIs
- 05Q25F6XJ3
- 21C3YS80Q6
- 41Z0077J45
- 42N66Q2197
- 65DL069QBP
- 7C8S056150
- 7SA290YK68
- B854H05S7D
- E8A73H7RG1
- EW7Q6SVD0D
- K3R6ZDH4DU
- P8272ET3N5
- PD6VU01UVN
- V7031C06AY
- ZNJ8R24I7Z
Other Registry Numbers
- 11104-36-2
- 11121-03-2
- 12626-85-6
- 128635-03-0
- 1307300-43-1
- 1415795-13-9
- 37224-17-2
- 60454-72-0
- 86280-85-5
- 9013-80-3
- 9044-66-0
- 911319-01-2
System Generated Number
- 0009004540
Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mammal (species unspecified) | LD50 | unreported | 13500mg/kg (13500mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Gematologiya i Transfuziologiya. Hematology and Transfusion Science. Vol. 31(10), Pg. 38, 1986. |
| mouse | LD50 | intravenous | 12100mg/kg (12100mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972. | |
| mouse | LD50 | oral | > 12gm/kg (12000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972. | |
| mouse | LD50 | subcutaneous | 13900mg/kg (13900mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972. | |
| rabbit | LD50 | intravenous | 17400mg/kg (17400mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972. |
| rabbit | LD50 | intravenous | 208gm/kg (208000mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 201, 1975. |
| rat | LD50 | intravenous | 6900mg/kg (6900mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972. | |
| rat | LD50 | oral | > 3gm/kg (3000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972. | |
| rat | LD50 | subcutaneous | 10700mg/kg (10700mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972. | |
| women | TDLo | intravenous | 6mg/kg (6mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" VASCULAR: OTHER CHANGES CARDIAC: OTHER CHANGES | British Medical Journal. Vol. 2, Pg. 1502, 1976. |