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Substance Name: Hydroxypropyl methylcellulose
RN: 9004-65-3

Note

  • Polymeric compounds that contain repeating units of hydroxypropyl methylcellulose. The properties of hypromellose polymers can vary greatly and are defined by their molecular weight, the percentage of hydroxyl groups, the percentage of hydroxypropyl groups, and viscosity measurements. They are found a broad variety of commercial products such as FOOD ADDITIVES; EXCIPIENTS; and LUBRICANTS.

Molecular Formula

  • C3-H8-O2.x-C-H4-O.x-Unspecified

Molecular Weight

  • 318.233
 

Classification Codes

  • Drug / Therapeutic Agent
  • Ophthalmic Solutions
  • Pharmaceutic Aid (Suspending Agent)
  • Pharmaceutic Aid (Tablet Excipient)
  • Pharmaceutic Aid (Viscosity-Increasing Agent)
  • Pharmaceutical Solutions
  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)

Names and Synonyms

Name of Substance

  • Carbohydrate gum
  • Cellulose, 2-hydroxypropyl methyl ether
  • Hydroxypropyl methylcellulose
  • Hydroxypropyl methylcellulose 1828 [USP]
  • Hypromellose
  • Hypromellose [INN]
  • Methyl hydroxypropyl cellulose

MeSH Heading

  • Hypromellose Derivatives

Synonyms

  • 2-Hydroxypropyl cellulose methyl ether
  • 2-Hydroxypropyl methyl cellulose
  • Cellulose hydroxypropyl methyl ether
  • Cellulose, 2-hydroxypropyl methyl ether
  • GenTeal
  • Goniosol
  • Hipromelosa
  • Hipromelosa [INN-Spanish]
  • Hipromelosa [Spanish]
  • Hpmcd
  • Hydroxypropyl methyl cellulose
  • Hydroxypropyl methylcellulose
  • Hydroxypropyl methylcellulose 1828
  • Hydroxypropylmethylcellulose
  • Hydroxypropylmethylcellulosum
  • Hypromellose
  • Hypromellose 2208 (100 MPA.S)
  • Hypromellose 2208 (15000 MPA.S)
  • HYPROMELLOSE 2906 (4000 MPA.S)
  • HYPROMELLOSE 2906 (50 MPA.S)
  • Hypromellose 2910 (15 MPA.S)
  • Hypromellose 2910 (15000 MPA.S)
  • Hypromellose 2910 (3 MPA.S)
  • Hypromellose 2910 (4000 MPA.S)
  • Hypromelloses
  • Hypromellosum
  • Hypromellosum [INN-Latin]
  • Hypromellosum [Latin]
  • Isopto alkaline
  • Isopto plain
  • Isopto Tears
  • Methocel E, F, J, K
  • Methocel E,F,K
  • Methocel HG
  • Methyl cellulose, propylene glycol ether
  • Methyl hydroxypropyl cellulose
  • Methylhydroxypropylcellulosum
  • Metolose
  • Tearisol
  • Ultra Tears
  • UNII-0HO1H52958
  • UNII-0VUT3PMY82
  • UNII-0WZ8WG20P6
  • UNII-1IVH67816N
  • UNII-288VBX44JC
  • UNII-2F7T07H9ZD
  • UNII-36SFW2JZ0W
  • UNII-39J80LT57T
  • UNII-3NXW29V3WO
  • UNII-58779NIC8P
  • UNII-5EYA69XGAT
  • UNII-612E703ZUQ
  • UNII-6531BH494O
  • UNII-9H4L916OBU
  • UNII-B1QE5P712K
  • UNII-R75537T0T4
  • UNII-RN3152OP35
  • UNII-VM7F0B23ZI
  • UNII-Z78RG6M2N2

Systematic Names

  • Cellulose, 2-hydroxypropyl methyl ether
  • Hydroxypropyl methylcellulose
  • Hypromellose

Superlist Names

  • 2-Hydroxypropyl methyl cellulose
  • Hydroxypropyl methylcellulose

Mixture Names

  • Estivin II
  • Isopto Frin
  • Tears Naturale

Registry Numbers

CAS Registry Number

  • 9004-65-3

FDA UNIIs

  • 0HO1H52958
  • 0VUT3PMY82
  • 0WZ8WG20P6
  • 1IVH67816N
  • 288VBX44JC
  • 2F7T07H9ZD
  • 36SFW2JZ0W
  • 39J80LT57T
  • 3NXW29V3WO
  • 58779NIC8P
  • 5EYA69XGAT
  • 612E703ZUQ
  • 6531BH494O
  • 9H4L916OBU
  • B1QE5P712K
  • R75537T0T4
  • RN3152OP35
  • VM7F0B23ZI
  • Z78RG6M2N2

Other Registry Numbers

  • 11106-33-5
  • 125053-98-7
  • 125857-43-4
  • 1262284-64-9
  • 12673-53-9
  • 137397-89-8
  • 137397-90-1
  • 137397-91-2
  • 171544-38-0
  • 173080-61-0
  • 194615-25-3
  • 37341-76-7
  • 39363-71-8
  • 59029-31-1
  • 62683-26-5
  • 65607-39-8
  • 68073-10-9
  • 71373-07-4
  • 8063-82-9
  • 98112-80-2

System Generated Number

  • 0009004653

Molecular Formulas

Molecular Formula

  • C3-H8-O2.x-C-H4-O.x-Unspecified

Molecular Formula Fragments

  • C-H4-O
  • C3-H8-O2
  • COMPONENT
  • Unspecified

Structure Descriptors

Smiles

O([C@H]1[C@@H]([C@H]([C@@H](*)O[C@@H]1CO*)O*)O*)[C@H]1[C@@H]([C@H]([C@H](O*)[C@H](O1)CO*)O*)O*

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 intraperitoneal > 2gm/kg (2000mg/kg)   Toksikologicheskii Vestnik. Vol. (6), Pg. 41, 1999.
mammal (species unspecified) LD50 oral > 10gm/kg (10000mg/kg)   Toksikologicheskii Vestnik. Vol. (6), Pg. 41, 1999.
mouse LD50 intraperitoneal 5gm/kg (5000mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 112, 1950.
rat LD50 intraperitoneal 5200mg/kg (5200mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 112, 1950.