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Substance Name: Hydroxyethyl starch 130/0.4 [USAN]
RN: 9005-27-0

Note

  • Starches that have been chemically modified so that a percentage of OH groups are substituted with 2-hydroxyethyl ether groups.

Molecular Formula

  • C2-H6-O2.x-Unspecified
 

Classification Codes

  • Blood Substitutes
  • Drug / Therapeutic Agent
  • Hematologic Agents
  • Leukopheresis Adjunct (Red Cell Sedimenting Agent)
  • Plasma Substitutes
  • Plasma Volume Extender
  • Prophylaxis of Hypervolemia
  • Reproductive Effect
  • TSCA Flag XU (Exempt from Reporting under the Inventory Update Rule)

Names and Synonyms

Results Name

  • Hydroxyethyl starch 130/0.4 [USAN]

Name of Substance

  • Hetastarch
  • Hetastarch [USAN:BAN]
  • Hydroxyethyl starch 130/0.4 [USAN]
  • Pentastarch [USAN:INN:BAN]

MeSH Heading

  • Hydroxyethyl Starch Derivatives

Synonyms

  • 2-Hydroxyethyl starch
  • 2-Hydroxyethyl starch ether
  • A starch composed of more than 90% amylopectin that has been etherified to the extent that an average of 4 to 5 of the OH groups present in every 10 D-glucopyranose units of the starch polymer have been converted to OCH2CH2OH groups. Starch 2-hydroxyethyl ether
  • ASL 607
  • ASL-607
  • Astro Gum 3020
  • Bohramyl
  • Elohast
  • Elohes
  • Essex 1360
  • Essex gum 1360
  • Ethylex gum 2020
  • Expafusion
  • HAS
  • HAS [German]
  • HES
  • HES 130/0.4
  • Hespan
  • Hespander
  • Hespander injection
  • Hetastarch
  • Hidroxietil almidon
  • Hydroxyathylstarke
  • Hydroxyathylstarke [German]
  • Hydroxyethyl starch
  • Hydroxyethyl starch 130/0.4
  • Hydroxyethylstarch
  • O-(2-Hydroxyethyl)starch
  • Onkohas
  • Penford 260
  • Penford 280
  • Penford 290
  • Penford P 208
  • Pentaspan
  • Pentastarch
  • Plasmasteril
  • Starch 2-hydroxyethyl ether
  • Tapioca starch hydroxyethyl ether
  • Tetraspan
  • Tetrastarch
  • UNII-1GVO236S58
  • UNII-875Y4127EA
  • UNII-MOQ3RNM0SV
  • Venofundin
  • Voluven

Systematic Name

  • Starch, 2-hydroxyethyl ether

Registry Numbers

CAS Registry Number

  • 9005-27-0

FDA UNIIs

  • 1GVO236S58
  • 875Y4127EA
  • MOQ3RNM0SV

Other Registry Numbers

  • 115252-32-9
  • 204144-00-3
  • 39363-84-3
  • 39363-85-4
  • 62253-20-7
  • 73666-73-6
  • 87140-13-4
  • 9057-07-2
  • 936087-55-7
  • 936087-60-4

System Generated Number

  • 0009005270

Molecular Formulas

Molecular Formula

  • C2-H6-O2.x-Unspecified

Molecular Formula Fragments

  • C2-H6-O2
  • COMPONENT
  • Unspecified

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 300gm/kg (300000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 16, Pg. 431, 1974.
mouse LD50 intravenous 20300mg/kg (20300mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.
mouse LD50 oral > 12gm/kg (12000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.
mouse LD50 subcutaneous > 18gm/kg (18000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.
rabbit LD50 intravenous 8460mg/kg (8460mg/kg)   Drugs in Japan Vol. -, Pg. 1007, 1995.
rat LD50 intraperitoneal > 300gm/kg (300000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 16, Pg. 431, 1974.
rat LD50 intravenous 8280mg/kg (8280mg/kg)   Drugs in Japan Vol. -, Pg. 1007, 1995.
rat LD50 oral > 50gm/kg (50000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 16, Pg. 431, 1974.
rat LD50 subcutaneous > 18gm/kg (18000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.