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Substance Name: Polysorbate 20 [USAN:INN:BAN:NF]
RN: 9005-64-5

Note

  • Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.

Molecular Formulas

  • C58-H114-O26
  • Unspecified

Molecular Weight

  • 520.6552
 

Classification Codes

  • Drug / Therapeutic Agent
  • Pharmaceutic Aid (Surfactant)
  • Reproductive Effect
  • Skin / Eye Irritant
  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)

Names and Synonyms

Name of Substance

  • PEG-10 Sorbitan laurate
  • PEG-40 Sorbitan laurate
  • PEG-44 Sorbitan laurate
  • PEG-75 Sorbitan laurate
  • PEG-80 Sorbitan laurate
  • Polyethylene glycol (44) sorbitan monolaurate
  • Polyethylene glycol (80) sorbitan monolaurate
  • Polyethylene glycol 2000 sorbitan laurate
  • Polyethylene glycol 4000 sorbitan monolaurate
  • Polyethylene glycol 500 sorbitan monolaurate
  • Polyoxyethylene (10) sorbitan monolaurate
  • Polyoxyethylene (20) sorbitan monolaurate
  • Polyoxyethylene (4) sorbitan monolaurate
  • Polyoxyethylene (40) sorbitan laurate
  • Polyoxyethylene (44) sorbitan monolaurate
  • Polyoxyethylene (75) sorbitan monolaurate
  • Polyoxyethylene (80) sorbitan monolaurate
  • Polysorbate 20
  • Polysorbate 20 [USAN:INN:BAN:NF]
  • Polysorbate 21
  • Sorbimacrogol laurate 300
  • Sorbitan, monododecanoate, poly(oxy-1,2-ethanediyl) derivs.

Synonyms

  • Armotan pml-20
  • Capmul
  • CCRIS 699
  • Dxewmulse poe-sml
  • EC 500-018-3
  • Emsorb 6915
  • FEMA No. 2915
  • Glycosperse L-20
  • Glycosperse L-20X
  • Hodag psml-20
  • HSDB 7824
  • Liposorb L-20
  • Peg sorbitan laurate
  • Peg-20 sorbitan laurate
  • Poe 20 sorbitan monolaurate
  • Polyoxyethylene 20 sorbitan monolaurate
  • Polyoxyethylene sorbitan monolaurate
  • Polyoxyethylene(4)sorbitan monolaurate
  • Polysorbate 20
  • Polysorbate 21
  • Protasorb L-20
  • PSML
  • Sorbimacrogol laurate 300
  • Sorbitan, monododecanoate, poly(oxy-1,2-ethanediyl) derivs.
  • Sorbitan, monododecanote, poly(oxy-1,2-ethanediyl) derivatives
  • Sorbitan, monolaurate, polyoxyethylene derivs.
  • Tween 20
  • Tween 21
  • UNII-239B50Y732
  • UNII-31JQ3WOL8T
  • UNII-4Z93U4C2WN
  • UNII-59IO08SBZU
  • UNII-7T1F30V5YH
  • UNII-I42X3Q0FMF

Systematic Names

  • Polyoxyethylene sorbitan monolaurate
  • Polysorbate 20
  • Sorbitan monolaurate, ethoxylated
  • Sorbitan, monododecanoate, poly(oxy-1,2-ethanediyl) derivs.

Superlist Names

  • Polyoxyethylene sorbitan monolaurate
  • Polysorbate 20

Registry Numbers

CAS Registry Number

  • 9005-64-5

FDA UNIIs

  • 239B50Y732
  • 31JQ3WOL8T
  • 4Z93U4C2WN
  • 59IO08SBZU
  • 7T1F30V5YH
  • I42X3Q0FMF

Other Registry Numbers

  • 118955-39-8
  • 122304-31-8
  • 1242241-45-7
  • 129428-64-4
  • 1341-06-6
  • 1646144-25-3
  • 194879-92-0
  • 37310-96-6
  • 54174-54-8
  • 60318-54-9
  • 62229-28-1
  • 8036-82-6
  • 851015-03-7
  • 861842-35-5
  • 9011-30-7
  • 9015-57-0
  • 93037-36-6

System Generated Number

  • 0009005645

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
hamster LD50 oral 18mL/kg (18mL/kg)   Food Research. Vol. 21, Pg. 348, 1956.
mouse LD50 intraperitoneal 2640mg/kg (2640mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
mouse LD50 intravenous 1420mg/kg (1420mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 316, 1970.
mouse LD50 oral > 33gm/kg (33000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
rat LD50 intraperitoneal 3850mg/kg (3850mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
rat LD50 intravenous 770mg/kg (770mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
rat LD50 oral 36700uL/kg (36.7mL/kg)   Food Research. Vol. 21, Pg. 348, 1956.