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Substance Name: Polysorbate 80 [USAN:INN:BAN:JAN:NF]
RN: 9005-65-6

Note

  • Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.

Molecular Formula

  • Unspecified

Molecular Weight

  • 604.816
 

Classification Codes

  • Mutation Data
  • Pharmaceutic Aid (Surfactant)
  • Reproductive Effect
  • Skin / Eye Irritant
  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
  • Tumor Data

Names and Synonyms

Name of Substance

  • PEG-3 Sorbitan oleate
  • PEG-6 Sorbitan oleate
  • Polyethylene glycol (3) sorbitan monooleate
  • Polyethylene glycol 300 sorbitan monooleate
  • Polyoxyethylene (20) sorbitan monooleate
  • Polyoxyethylene (3) sorbitan monooleate
  • Polyoxyethylene (5) sorbitan monooleate
  • Polysorbate 80
  • Polysorbate 80 [USAN:INN:BAN:JAN:NF]
  • Polysorbate 81
  • Sorbimacrogol oleate 300
  • Sorbitan, mono-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs.

Synonyms

  • Akamuls PSMO 20
  • Alkamuls T 80
  • Armotan pmo-20
  • Atlox 1087
  • Atlox 8916TF
  • Avitears
  • Capmul poe-O
  • CCRIS 700
  • Cemerol T 80
  • Cemesol TW 1020
  • Crill 10
  • Crill 11
  • Crill S 10
  • Crillet 4
  • Crillet 4 Super
  • Crillet 41
  • Disponil SMO 120
  • Drewmulse poe-smo
  • Durfax 80
  • EC 500-019-9
  • Ecoteric T 80
  • Emasol O 105R
  • Emsorb 6900
  • Emulson 100M
  • Ethoxylated sorbitan monooleate
  • Eumulgin SMO 20
  • FEMA No. 2917
  • Flo Mo SMO 20
  • Glycols, polyethylene, ether with sorbitan monooleate
  • Glycosperse O 20
  • Glycosperse O 5
  • Glycosperse O-20
  • Glycosperse O-20 VEG
  • Glycosperse O-20X
  • Hodag SVO 9
  • HSDB 4359
  • MO 55F
  • Monitan
  • Montanox 80
  • Myvatex MSPS
  • NCI-C60286
  • Nikkol TO
  • Nikkol TO 10
  • Nikkol TO 10M
  • Nissan Nonion OT 221
  • Nonion OT 221
  • Olothorb
  • Peg sorbitan oleate
  • Peg-20 sorbitan oleate
  • Polisorbac 60
  • Polyethylene oxide sorbitan mono-oleate
  • Polyoxyethylene 20 sorbitan monooleate
  • Polyoxyethylene sorbitan monooleate
  • Polyoxyethylene sorbitan oleate
  • Polyoxyethylene(20) sorbitan monooleate
  • Polysorban 80
  • Polysorbate 80
  • Polysorbate 80 B.P.C.
  • Polysorbate 80 BPC
  • Polysorbate 80, U.S.P.
  • Polysorbate 80, USP
  • Polysorbate 81
  • Protasorb O-20
  • Romulgin O
  • Sorbimacrogol oleate
  • Sorbimacrogol oleate 300
  • Sorbital 0 20
  • Sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl) derivatives
  • Sorbitan, monooleate, polyoxyethylene derivs
  • Sorbon T 80
  • Sorethytan (20) monooleate
  • Sorethytan oleate
  • Sorlate
  • SVO 9
  • TO 10
  • Tween 80
  • Tween 80 A
  • Tween 81
  • UNII-2MSF640LWM
  • UNII-58O7V09UCI
  • UNII-6OZP39ZG8H

Systematic Names

  • Polyoxyethylene sorbitan monooleate
  • Sorbitan monooleate, ethoxylated
  • Sorbitan, mono-(9Z)-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs.
  • Sorbitan, mono-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs., (Z)-
  • Sorbitan, monooleate polyoxyethylene deriv.

Superlist Names

  • Glycol
  • Poly(20)oxyethylene sorbitan monooleate
  • Polyoxyethylene sorbitan monooleate
  • Polysorbate 80

Mixture Name

  • Rohto

Registry Numbers

CAS Registry Number

  • 9005-65-6

FDA UNIIs

  • 2MSF640LWM
  • 58O7V09UCI
  • 6OZP39ZG8H

Other Registry Numbers

  • 1286269-72-4
  • 1340-85-8
  • 141927-23-3
  • 178631-96-4
  • 209796-63-4
  • 2137448-98-5
  • 253447-34-6
  • 361534-35-2
  • 37199-23-8
  • 37280-84-5
  • 51377-27-6
  • 541509-66-4
  • 61723-75-9
  • 8050-83-7
  • 900143-89-7
  • 9015-07-0
  • 9050-49-1
  • 9050-57-1

System Generated Number

  • 0009005656

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 500mg/kg (500mg/kg) CARDIAC: OTHER CHANGES

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1586, 1978.
dog LDLo intravenous 500mg/kg (500mg/kg) CARDIAC: OTHER CHANGES

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1586, 1978.
mammal (species unspecified) LD50 intravenous 5800mg/kg (5800mg/kg)   Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 26, Pg. 459, 1991.
mammal (species unspecified) LD50 oral 25gm/kg (25000mg/kg)   Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 26, Pg. 459, 1991.
mouse LD50 intraperitoneal 7600mg/kg (7600mg/kg)   Pharmacology and Therapeutics. Vol. 5, Pg. 467, 1979.
mouse LD50 intravenous 4500mg/kg (4500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 666, 1968.
mouse LD50 oral 25gm/kg (25000mg/kg)   Bollettino Chimico Farmaceutico. Vol. 101, Pg. 173, 1962.
rat LD50 intraperitoneal 6804mg/kg (6804mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 804, 1985.
rat LD50 intravenous 1790mg/kg (1790mg/kg)   FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 254, 1974.
rat LD50 oral 34500uL/kg (34.5mL/kg)   Food Research. Vol. 21, Pg. 348, 1956.