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Substance Name: Crotoxin
RN: 9007-40-3

Note

  • A specific complex of toxic proteins from the venom of Crotalus durissus terrificus (South American rattlesnake). It can be separated into a phospholipase A and crotapotin fragment; the latter consists of three different amino acid chains, potentiates the enzyme, and is specifically neurotoxic.

Molecular Formula

  • Unspecified
 

Classification Code

  • Natural Product
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Names and Synonyms

Name of Substance

  • Crotoxin

MeSH Heading

  • Crotoxin

Synonyms

  • Crotalus spp. crotoxin
  • Crotoxin (Crotalus spp.)
  • Phospholipase (Crotalus spp.)
  • Snake toxins

Systematic Name

  • Crotoxin

Registry Numbers

CAS Registry Number

  • 9007-40-3

System Generated Number

  • 0009007403

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 300ug/kg (0.3mg/kg)   Toxicology. Vol. 99, Pg. 31, 1995.
mouse LD50 intraperitoneal 62ug/kg (0.062mg/kg)   Toxicon. Vol. 28, Pg. 1491, 1990.
mouse LD50 intravenous 49ug/kg (0.049mg/kg)   Toxicon. Vol. 32, Pg. 217, 1994.
mouse LD50 subcutaneous 178ug/kg (0.178mg/kg)   Toxicon. Vol. 19, Pg. 875, 1981.
mouse LD50 unreported 65ug/kg (0.065mg/kg)   Toxicon. Vol. 8, Pg. 135, 1970.
pigeon LD50 intravenous 2170ng/kg (0.00217mg/kg)   Tai-wan I Hsueh Hui Tsa Chih. Journal of the Formosan Medical Association. Vol. 71, Pg. 394, 1972.