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Substance Name: Globulin, Immune [USP]
RN: 9007-83-4

Note

  • Serum globulins that migrate to the gamma region (most positively charged) upon ELECTROPHORESIS. At one time, gamma-globulins came to be used as a synonym for immunoglobulins since most immunoglobulins are gamma globulins and conversely most gamma globulins are immunoglobulins. But since some immunoglobulins exhibit an alpha or beta electrophoretic mobility, that usage is in decline.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Human Data
  • Immunologic Factors
  • Natural Product

Names and Synonyms

Name of Substance

  • Globulin, Immune [USP]

MeSH Heading

  • gamma-Globulins

Synonyms

  • Carimune
  • Cuvitru
  • EINECS 232-706-1
  • Gamimune N
  • Gamma globulin
  • gamma-Globulin
  • Gammagard
  • Gammaglobulin
  • Gamunex
  • Globulin, Immune
  • Human immune globulin g
  • Immune endoglobulin
  • Immune Globulin
  • Immunoglobulin
  • IVIG
  • Privigen
  • Sandoglobulin
  • Vivaglobin

Systematic Name

  • Globulins, gamma-

Registry Numbers

CAS Registry Number

  • 9007-83-4

System Generated Number

  • 0009007834

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo intravenous 2gm/kg/94D-I (2000mg/kg) BLOOD: AGRANULOCYTOSIS British Medical Journal. Vol. 296, Pg. 1262, 1988.
guinea pig LD50 intravenous > 8gm/kg (8000mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2118, 1971.
guinea pig LD50 subcutaneous > 6gm/kg (6000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 2118, 1971.
man TDLo intravenous 28571ug/kg/5D (28.571mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Archives of Internal Medicine. Vol. 154, Pg. 1985, 1994.
man TDLo intravenous 1340mg/kg/2D- (1340mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
American Journal of Kidney Diseases. Vol. 25, Pg. 228, 1995.
man TDLo intravenous 2gm/kg/5D-I (2000mg/kg) KIDNEY, URETER, AND BLADDER: HEMATURIA

KIDNEY, URETER, AND BLADDER: PROTEINURIS

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
New England Journal of Medicine. Vol. 327, Pg. 1032, 1992.
man TDLo intravenous 2800mg/kg/7D- (2800mg/kg) BLOOD: NORMOCYTIC ANEMIA American Journal of Medicine. Vol. 82, Pg. 633, 1987.
mouse LD oral > 15gm/kg (15000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1932, 1971.
mouse LD50 intravenous > 11gm/kg (11000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 89, 1979.
mouse LD50 subcutaneous > 15gm/kg (15000mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 89, 1979.
rat LD oral > 15gm/kg (15000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1932, 1971.
rat LD50 intravenous > 11gm/kg (11000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 89, 1979.
rat LD50 subcutaneous > 15gm/kg (15000mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 89, 1979.