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Substance Name: Glucagon
RN: 9007-92-5
InChIKey: MASNOZXLGMXCHN-ZLPAWPGGSA-N

Notes

  • A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)
  • Prefer explicit peptides, this general immunoreactivity term has declining use; kept for historical purposes; peptides which have an immunodeterminant similar to the 2-23 region of glucagon, but not immunodeterminant similar to glucagon.

Molecular Formula

  • Unspecified

Molecular Weight

  • 3482.7785
 

Classification Codes

  • Gastrointestinal Agents
  • Hormone
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Mutation Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Glucagon
  • Glucagon-like-immunoreactivity

MeSH Heading

  • Glucagon

Synonyms

  • EINECS 232-708-2
  • Glucagon
  • Glucagon-like-immunoreactivity
  • His-ser-glu(nh2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-glu(NH2)-asp-phe-val-glu(NH2)-trp-leu-met-asp(NH2)-thr
  • HSDB 3337

Systematic Name

  • Glucagon

Registry Numbers

CAS Registry Number

  • 9007-92-5

Other Registry Numbers

  • 12709-67-0
  • 37307-57-6
  • 37328-81-7
  • 82905-30-4

System Generated Number

  • 0009007925

Structure Descriptors

InChI

1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1

InChIKey

MASNOZXLGMXCHN-ZLPAWPGGSA-N

Smiles

N([C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)[C@@H](O)C)CC(=O)N)CCSC)CC(C)C)Cc1c[nH]c2c1cccc2)CCC(=O)N)[C@@H](C)C)Cc1ccccc1)CC(=O)O)CCC(=O)N)CCCNC(=N)N)CCCNC(=N)N)CO)CC(=O)O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1[nH]cnc1)CO)CCC(=O)N)[C@@H](O)C)Cc1ccccc1)[C@@H](O)C)CO)CC(=O)O)Cc1ccc(cc1)O)CO)CCCCN)Cc1ccc(cc1)O)CC(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous > 10mg/kg (10mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
mouse LD50 intramuscular > 200mg/kg (200mg/kg)   Drugs in Japan Vol. 6, Pg. 224, 1982.
mouse LD50 intraperitoneal > 200mg/kg (200mg/kg)   Drugs in Japan Vol. 6, Pg. 224, 1982.
mouse LD50 intravenous 200mg/kg (200mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
mouse LD50 subcutaneous > 200mg/kg (200mg/kg)   Drugs in Japan Vol. 6, Pg. 224, 1982.
rat LD50 intramuscular > 200mg/kg (200mg/kg)   Drugs in Japan Vol. 6, Pg. 224, 1982.
rat LD50 intraperitoneal > 200mg/kg (200mg/kg)   Drugs in Japan Vol. 6, Pg. 224, 1982.
rat LD50 intravenous 100mg/kg (100mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
rat LD50 subcutaneous 200mg/kg (200mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.