Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Protamine sulfate [USP:INN:BAN:JAN]
RN: 9009-65-8
UNII: 0DE9724IHC

Note

  • A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)

Molecular Formula

  • Unspecified
 

Classification Codes

  • Antidote (to Heparin)
  • Coagulants
  • Drug / Therapeutic Agent
  • Hematologic Agents
  • Heparin Antagonists
  • Human Data
  • Reproductive Effect
  • TSCA UVCB
* denotes mobile formatted website

Links to Resources

Names and Synonyms

Name of Substance

  • Protamine sulfate
  • Protamine sulfate [USP:INN:BAN:JAN]

MeSH Heading

  • Protamines

Synonyms

  • Angiociclan
  • CCRIS 8521
  • Dilangio
  • Fluxema
  • Protamina solfato
  • Protamina solfato [DCIT]
  • Protamine sulfate
  • Protamine sulphate
  • Protamini sulfas
  • Protamini sulfas [Latin]
  • Sulfate de protamine
  • Sulfate de protamine [French]
  • Sulfato de protamina
  • Sulfato de protamina [Spanish]
  • UNII-0DE9724IHC
  • USAF D-4
  • Vasorelax

Systematic Names

  • Protamine, sulfate
  • Protamines, sulfates

Registry Numbers

CAS Registry Number

  • 9009-65-8

FDA UNII

  • 0DE9724IHC

System Generated Number

  • 0009009658

Structure Descriptors

Smiles

[*]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 120mg/kg (120mg/kg)   Drugs in Japan Vol. 6, Pg. 726, 1982.
guinea pig LD50 intravenous 120mg/kg (120mg/kg)   Drugs in Japan Vol. 6, Pg. 726, 1982.
guinea pig LD50 subcutaneous 200mg/kg (200mg/kg)   Drugs in Japan Vol. 6, Pg. 726, 1982.
man LDLo intravenous 2174ug/kg/25M (2.174mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
Drug Intelligence and Clinical Pharmacy. Vol. 22, Pg. 211, 1988.
mouse LD50 intraperitoneal 94mg/kg (94mg/kg)   Drugs in Japan Vol. 6, Pg. 726, 1982.
mouse LD50 intravenous 38mg/kg (38mg/kg)   Russian Pharmacology and Toxicology Vol. 38, Pg. 73, 1975.
mouse LD50 subcutaneous 200mg/kg (200mg/kg)   Drugs in Japan Vol. 6, Pg. 726, 1982.
rabbit LD50 subcutaneous 200mg/kg (200mg/kg)   Drugs in Japan Vol. 6, Pg. 726, 1982.
rat LD50 intraperitoneal 120mg/kg (120mg/kg)   Drugs in Japan Vol. 6, Pg. 726, 1982.
rat LD50 intravenous 75mg/kg (75mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 165, Pg. 374, 1967.