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Substance Name: Ricin
RN: 9009-86-3
UNII: U6E7R9OE4R

Note

  • A protein phytotoxin from the seeds of Ricinus communis, the castor oil plant. It agglutinates cells, is proteolytic, and causes lethal inflammation and hemorrhage if taken internally.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Agricultural Chemical
  • Chemical Warfare Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Natural Product
  • Noxae
  • Poisons
  • Reproductive Effect
  • Rodenticide
  • Skin / Eye Irritant
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Links to Resources

Names and Synonyms

Name of Substance

  • Ricin

MeSH Heading

  • Ricin

Synonyms

  • Agent W
  • Castor Bean Lectin
  • HSDB 3566
  • Proteins, ricins
  • Proteins, specific or class, ricins
  • Ricin
  • Ricin (Ricinus communis, seeds)
  • Ricine
  • Ricins
  • Ricinus lectin
  • Ricinus toxin
  • UNII-U6E7R9OE4R

Systematic Names

  • Ricin
  • Ricins

Superlist Name

  • Ricin

Registry Numbers

CAS Registry Number

  • 9009-86-3

FDA UNII

  • U6E7R9OE4R

Other Registry Number

  • 9067-26-9

System Generated Number

  • 0009009863

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intratracheal 5ug/kg (0.005mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
National Technical Information Service. Vol. PB158-508,
cat LD50 unreported 200ng/kg (0.0002mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
National Technical Information Service. Vol. PB158-508,
child LDLo unreported 500ug/kg (0.5mg/kg) GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: HEADACHE
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 158, 1969.
dog LD50 intramuscular 600ng/kg (0.0006mg/kg)   "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1454, 1986.
dog LD50 intratracheal 5ug/kg (0.005mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
National Technical Information Service. Vol. PB158-508,
dog LD50 unreported 600ng/kg (0.0006mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
National Technical Information Service. Vol. PB158-508,
dog LDLo intravenous 1600ng/kg (0.0016mg/kg)   Journal of Toxicology and Environmental Health. Vol. 5, Pg. 1073, 1979.
dog LDLo intravenous 1600ng/kg (0.0016mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Journal of Toxicology and Environmental Health. Vol. 5, Pg. 1073, 1979.
dog LDLo parenteral 30ug/kg (0.03mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"
Acta Pharmacologica et Toxicologica, Supplementun. Vol. 41, Pg. 351, 1977.
domestic animals - goat/sheep LD50 unreported 3ug/kg (0.003mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
National Technical Information Service. Vol. PB158-508,
guinea pig LD50 unreported 800ng/kg (0.0008mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
National Technical Information Service. Vol. PB158-508,
guinea pig LDLo intraperitoneal 20ng/kg (0.00002mg/kg)   Science. Vol. 144, Pg. 1100, 1964.
human LDLo oral 2mg/kg (2mg/kg)   Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 963, 1966.
man LDLo oral 300ug/kg (0.3mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
National Technical Information Service. Vol. PB158-508,
man LDLo subcutaneous 43ug/kg (0.043mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Acta Pharmacologica et Toxicologica, Supplementun. Vol. 41, Pg. 351, 1977.
man TDLo oral 900ug/kg (0.9mg/kg)   Human Toxicology. Vol. 2, Pg. 239, 1983.
man TDLo oral 900ug/kg (0.9mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: NAUSEA OR VOMITING
Human Toxicology. Vol. 2, Pg. 239, 1983.
mouse LD50 intraperitoneal 2ug/kg (0.002mg/kg)   Toxicon. Vol. 18, Pg. 649, 1980.
mouse LD50 intravenous 2200ng/kg (0.0022mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
National Technical Information Service. Vol. PB158-508,
mouse LD50 subcutaneous 22100ng/kg (0.0221mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
National Technical Information Service. Vol. PB158-508,
mouse LD50 unreported 6ug/kg (0.006mg/kg)   Biochimica et Biophysica Acta. Vol. 295, Pg. 582, 1973.
mouse LDLo oral 30mg/kg (30mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Chemical and Pharmaceutical Bulletin. Vol. 31, Pg. 3222, 1983.
rabbit LD50 intratracheal 500ng/kg (0.0005mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
National Technical Information Service. Vol. PB158-508,
rabbit LD50 intravenous 540ng/kg (0.00054mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION Pharmacology and Toxicology Vol. 74, Pg. 148, 1994.
rabbit LD50 unreported 100ng/kg (0.0001mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
National Technical Information Service. Vol. PB158-508,
rabbit LDLo oral 500ug/kg (0.5mg/kg)   Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 963, 1966.
rat LD50 intraperitoneal 1500ng/kg (0.0015mg/kg)   Toxicon. Vol. 18, Pg. 649, 1980.
rat LD50 intratracheal 5ug/kg (0.005mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
National Technical Information Service. Vol. PB158-508,
rat LD50 parenteral 336ng/kg (0.000336mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Neurochemical Research. Vol. 4, Pg. 259, 1979.
rat LD50 unreported 4ug/kg (0.004mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
National Technical Information Service. Vol. PB158-508,
rat LDLo oral 30mg/kg (30mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Chemical and Pharmaceutical Bulletin. Vol. 31, Pg. 3222, 1983.