Substance Name: Ricin
RN: 9009-86-3
UNII: U6E7R9OE4R
Note
- A protein phytotoxin from the seeds of Ricinus communis, the castor oil plant. It agglutinates cells, is proteolytic, and causes lethal inflammation and hemorrhage if taken internally.
Molecular Formula
- Unspecified
Classification Codes
- Agricultural Chemical
- Chemical Warfare Agents
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Natural Product
- Noxae
- Poisons
- Reproductive Effect
- Rodenticide
- Skin / Eye Irritant
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Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Names and Synonyms
Name of Substance
- Ricin
MeSH Heading
- Ricin
Synonyms
- Agent W
- Castor Bean Lectin
- HSDB 3566
- Proteins, ricins
- Proteins, specific or class, ricins
- Ricin
- Ricin (Ricinus communis, seeds)
- Ricine
- Ricins
- Ricinus lectin
- Ricinus toxin
- UNII-U6E7R9OE4R
Systematic Names
- Ricin
- Ricins
Superlist Name
- Ricin
Registry Numbers
CAS Registry Number
- 9009-86-3
FDA UNII
- U6E7R9OE4R
Other Registry Number
- 9067-26-9
System Generated Number
- 0009009863
Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | intratracheal | 5ug/kg (0.005mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | National Technical Information Service. Vol. PB158-508, |
| cat | LD50 | unreported | 200ng/kg (0.0002mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA | National Technical Information Service. Vol. PB158-508, |
| child | LDLo | unreported | 500ug/kg (0.5mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: HEADACHE GASTROINTESTINAL: OTHER CHANGES | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 158, 1969. |
| dog | LD50 | intramuscular | 600ng/kg (0.0006mg/kg) | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1454, 1986. | |
| dog | LD50 | intratracheal | 5ug/kg (0.005mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | National Technical Information Service. Vol. PB158-508, |
| dog | LD50 | unreported | 600ng/kg (0.0006mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | National Technical Information Service. Vol. PB158-508, |
| dog | LDLo | intravenous | 1600ng/kg (0.0016mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: MUSCLE WEAKNESS | Journal of Toxicology and Environmental Health. Vol. 5, Pg. 1073, 1979. |
| dog | LDLo | parenteral | 30ug/kg (0.03mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Acta Pharmacologica et Toxicologica, Supplementun. Vol. 41, Pg. 351, 1977. |
| domestic animals - goat/sheep | LD50 | unreported | 3ug/kg (0.003mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | National Technical Information Service. Vol. PB158-508, |
| guinea pig | LD50 | unreported | 800ng/kg (0.0008mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | National Technical Information Service. Vol. PB158-508, |
| guinea pig | LDLo | intraperitoneal | 20ng/kg (0.00002mg/kg) | Science. Vol. 144, Pg. 1100, 1964. | |
| human | LDLo | oral | 2mg/kg (2mg/kg) | Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 963, 1966. | |
| man | LDLo | oral | 300ug/kg (0.3mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING | National Technical Information Service. Vol. PB158-508, |
| man | LDLo | subcutaneous | 43ug/kg (0.043mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Acta Pharmacologica et Toxicologica, Supplementun. Vol. 41, Pg. 351, 1977. |
| man | TDLo | oral | 900ug/kg (0.9mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Human Toxicology. Vol. 2, Pg. 239, 1983. |
| mouse | LD50 | intraperitoneal | 2ug/kg (0.002mg/kg) | Toxicon. Vol. 18, Pg. 649, 1980. | |
| mouse | LD50 | intravenous | 2200ng/kg (0.0022mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | National Technical Information Service. Vol. PB158-508, |
| mouse | LD50 | subcutaneous | 22100ng/kg (0.0221mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | National Technical Information Service. Vol. PB158-508, |
| mouse | LD50 | unreported | 6ug/kg (0.006mg/kg) | Biochimica et Biophysica Acta. Vol. 295, Pg. 582, 1973. | |
| mouse | LDLo | oral | 30mg/kg (30mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Chemical and Pharmaceutical Bulletin. Vol. 31, Pg. 3222, 1983. |
| rabbit | LD50 | intratracheal | 500ng/kg (0.0005mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA | National Technical Information Service. Vol. PB158-508, |
| rabbit | LD50 | intravenous | 540ng/kg (0.00054mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Pharmacology and Toxicology Vol. 74, Pg. 148, 1994. |
| rabbit | LD50 | unreported | 100ng/kg (0.0001mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | National Technical Information Service. Vol. PB158-508, |
| rabbit | LDLo | oral | 500ug/kg (0.5mg/kg) | Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 963, 1966. | |
| rat | LD50 | intraperitoneal | 1500ng/kg (0.0015mg/kg) | Toxicon. Vol. 18, Pg. 649, 1980. | |
| rat | LD50 | intratracheal | 5ug/kg (0.005mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | National Technical Information Service. Vol. PB158-508, |
| rat | LD50 | parenteral | 336ng/kg (0.000336mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Neurochemical Research. Vol. 4, Pg. 259, 1979. |
| rat | LD50 | unreported | 4ug/kg (0.004mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA | National Technical Information Service. Vol. PB158-508, |
| rat | LDLo | oral | 30mg/kg (30mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Chemical and Pharmaceutical Bulletin. Vol. 31, Pg. 3222, 1983. |