Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Rebamipide [INN:JAN]
RN: 90098-04-7
UNII: LR583V32ZR
InChIKey: ALLWOAVDORUJLA-UHFFFAOYSA-N

Note

  • Inhibits gastric xanthine oxidase.

Molecular Formula

  • C19-H15-Cl-N2-O4

Molecular Weight

  • 370.7905
 

Classification Codes

  • Anti-Ulcer Agents
  • Antioxidants
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Gastrointestinal Agents
  • Protective Agents
  • Reproductive Effect
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Rebamipide
  • Rebamipide [INN:JAN]

Synonyms

  • (+-)-1,2-Dihydro-alpha-((4-chlorobenzoyl)amino)-2-oxo-4-quinolinepropanoic acid
  • (+-)-2-(4-Chlorobenzoylamino)-3-(2(1H)-quinolinon-4-yl)propionic acid
  • CCRIS 3585
  • Mucosta
  • OPC 12759
  • Proamipide
  • Rebamipide
  • Rebamipidum
  • Rebamipidum [INN-Latin]
  • UNII-LR583V32ZR

Systematic Names

  • (+-)-2-(4-Chlorobenzoylamino)-3-(2(1H)-quinolinon-4-yl)propionic acid
  • 4-Quinolinepropanoic acid, 1,2-dihydro-alpha-((4-chlorobenzoyl)amino)-2-oxo-, (+-)-

Registry Numbers

CAS Registry Number

  • 90098-04-7

FDA UNII

  • LR583V32ZR

Other Registry Numbers

  • 111911-87-6
  • 139344-42-6

System Generated Number

  • 0090098047

Structure Descriptors

InChI

1S/C19H15ClN2O4/c20-13-7-5-11(6-8-13)18(24)22-16(19(25)26)9-12-10-17(23)21-15-4-2-1-3-14(12)15/h1-8,10,16H,9H2,(H,21,23)(H,22,24)(H,25,26)

InChIKey

ALLWOAVDORUJLA-UHFFFAOYSA-N

Smiles

[nH]1c(=O)cc(c2ccccc12)CC(C(=O)O)NC(=O)c1ccc(cc1)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. -, Pg. 1458, 1995.
dog LD50 oral > 2gm/kg (2000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
mouse LD50 intramuscular 1353mg/kg (1353mg/kg)   Drugs in Japan Vol. -, Pg. 1458, 1995.
mouse LD50 intramuscular 1353mg/kg (1353mg/kg) BLOOD: CHANGES IN SPLEEN

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
mouse LD50 intravenous 500mg/kg (500mg/kg)   Drugs in Japan Vol. -, Pg. 1458, 1995.
mouse LD50 intravenous 572mg/kg (572mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 1458, 1995.
mouse LD50 subcutaneous 2gm/kg (2000mg/kg)   Drugs in Japan Vol. -, Pg. 1458, 1995.
mouse LD50 subcutaneous 2637mg/kg (2637mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
mouse LDLo oral > 5gm/kg (5000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
rabbit LD50 oral > 3gm/kg (3000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
rat LD50 intramuscular > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. -, Pg. 1458, 1995.
rat LD50 intravenous 700mg/kg (700mg/kg)   Drugs in Japan Vol. -, Pg. 1458, 1995.
rat LD50 intravenous 700mg/kg (700mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
rat LD50 intravenous 700mg/kg (700mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
rat LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 1458, 1995.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. -, Pg. 1458, 1995.
rat LDLo intramuscular 1gm/kg (1000mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
rat LDLo oral 5gm/kg (5000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
rat LDLo oral 5gm/kg (5000mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.
rat LDLo subcutaneous 4gm/kg (4000mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 362, 1989.