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Substance Name: Nitroglycerin [USP:JAN]
RN: 55-63-0
UNII: G59M7S0WS3
InChIKey: SNIOPGDIGTZGOP-UHFFFAOYSA-N
Note
- A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
Molecular Formula
- C3-H5-N3-O9
Molecular Weight
- 227.085
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Antiviral (COVID-19)
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Explosive Agents
- Human Data
- Mutation Data
- Reproductive Effect
- Skin / Eye Irritant
- Tumor Data
- Vasodilator (Coronary)
- Vasodilator Agents
Superlist Classification Codes
- Ceiling 0.2 ppm (2 mg/m3); skin
- Reportable Quantity (RQ) = 10 lb
- TWA (0.05 ppm); skin
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NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
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Names and Synonyms
Name of Substance
- Nitroglycerin
- Nitroglycerin [USP:JAN]
MeSH Heading
- Nitroglycerin
Synonyms
- 1,2,3-Propanetriol, trinitrate
- 1,2,3-Propanetriyl nitrate
- 4-01-00-02762 (Beilstein Handbook Reference)
- Adesitrin
- Aldonitrin
- Angibid
- Anginine
- Angiolingual
- Angiplex
- Anglix
- Angonist
- Angorin
- Aquo-Trimitrosan
- Blasting gelatin
- Blasting oil
- BRN 1802063
- Buccard
- Cardabid
- Cardamist
- Cardinit
- Cardiodisco
- CCRIS 4089
- Chitamite
- Colenitral
- Corangin Nitrokapseln
- Cordipatch
- Corditrine
- Coro-Nitro
- Dauxona
- Deponit
- Deponit 5
- Deponit TTS 10
- Deponit TTS 5
- Deponit-5
- Diafusor
- Discotrine
- EC 200-240-8
- EINECS 200-240-8
- Epinitril
- Gepan Nitroglicerin
- Gilucor nitro
- Gilustenon
- Glonoin
- Glonoinum
- Glycerine trinitrate
- Glycerintrinitrate
- Glycerintrinitrate [Czech]
- Glycerol (trinitrate de)
- Glycerol (trinitrate de) [French]
- Glycerol trinitrate
- Glycerol(trinitrate de)
- Glycerol(trinitrate de) [French]
- Glycerol, nitric acid triester
- Glyceroltrinitraat
- Glyceroltrinitraat [Dutch]
- Glyceryl
- Glyceryl nitrate
- Glyceryl trinitrate
- Glycerylnitrat
- Glytrin
- Gonitro
- GTN
- GTN-Pohl
- Herwicard
- Herzer
- HSDB 30
- Klavikordal
- Lenitral
- Lentonitrina
- Mi-Trates
- Millisrol
- Minitram
- Minitran
- Mionitrat
- Myocon
- Myoglycerin
- Myovin
- Natispray
- Neos nitro OPT
- NG
- Niglin
- Niglycon
- Niong
- Niong Retard
- Nirmin
- Nit-Ret
- Nitora
- Nitradisc
- Nitradisc Pad
- Nitradisc TTS
- Nitrek
- Nitric acid triester of gylcerol
- Nitriderm TTS
- Nitrin
- Nitrine
- Nitrine-TDC
- Nitro Dur TTS
- Nitro IV
- Nitro Mack Retard
- Nitro Retard
- Nitro Rorer
- Nitro-Bid
- Nitro-Dur
- Nitro-Dur 10
- Nitro-Dur 5
- Nitro-Gesanit Retard
- Nitro-lent
- Nitro-M-Bid
- Nitro-Mack Retard
- Nitro-Par
- Nitro-Pflaster
- Nitro-Span
- Nitro-Time
- Nitroard
- Nitrobaat
- NitroBid
- Nitrobid Oint
- Nitrobukal
- NitrocapT.D.
- Nitrocerin
- Nitrocine
- Nitrocine 5
- Nitroclyn
- Nitrocontin
- Nitrocontin Continus
- Nitrocor
- Nitrocot
- Nitroderm
- Nitroderm TTS
- Nitroderm TTS Ext
- Nitroderm TTS-5
- Nitrodisc
- Nitrodyl
- Nitrodyl TTS
- Nitrogard
- Nitrogard-SR
- Nitroglicerina
- Nitroglicerina [Italian]
- Nitroglicerina [Spanish]
- Nitrogliceryna
- Nitrogliceryna [Polish]
- Nitroglin
- Nitroglycerin
- Nitroglycerin in dextrose 5%
- Nitroglycerin, spirits of
- Nitroglycerin-ACC
- Nitroglycerine
- Nitroglycerine [French]
- Nitroglycerol
- Nitroglyn
- Nitrol
- Nitrol (pharmaceutical)
- Nitrol Ointment
- Nitrolan
- Nitroletten
- Nitrolin
- Nitrolingual
- Nitrolingual pumpspray
- Nitrolingual Spray
- Nitrolowe
- Nitromack Retard
- Nitromel
- Nitromex
- Nitromint
- Nitromint Aerosol
- Nitromint Retard
- Nitromist
- Nitronal
- Nitronal Aqueous
- Nitronet
- Nitrong
- Nitrong Retard
- Nitrong-SR
- Nitropatch
- Nitropen
- Nitropercuten
- Nitroperlinit
- Nitroplast
- Nitroprol
- Nitropront
- Nitroprontan
- NitroQuick
- NitroQuik
- Nitrorectal
- Nitroretard
- Nitrorex
- Nitrospan
- Nitrostabilin
- Nitrostat
- Nitrovis
- Nitrozell retard
- NK-843
- NTG
- NTS
- Nysconitrine
- Percutol
- Percutol Oint.
- Perganit
- Perglottal
- Perlinganit
- Plastranit
- Polnitrin
- Propanetriol trinitrate
- Ratiopharm
- RCRA waste number P081
- Rectiv
- SK-106N
- Solution glyceryl trinitrate
- Soup
- Spirit of glonoin
- Spirit of glyceryl trinitrate
- Spirit of trinitroglycerin
- Spirits of Nitroglycerin, (1 to 10%)
- Susadrin
- Suscard
- Sustak
- Sustonit
- Temponitrin
- Top-Nitro
- Transderm Nitro
- Transderm-N TTS
- Transderm-Nitro
- Transderm-Nitro TTS
- Transiderm-Nitro
- Tridil
- Trinalgon
- Trinipatch
- Triniplas
- Trinitrin
- Trinitrina Erba
- Trinitrine Simple Laleuf
- Trinitroglicerina Fabra
- Trinitroglycerin
- Trinitroglycerol
- Trinitrol
- Trinitrolong
- Trinitron
- Trinitrosan
- Turicard
- UNII-G59M7S0WS3
- Vasoglyn
- Vasolator
- Vernies
- Willong
Systematic Names
- 1,2,3-Propanetriol, 1,2,3-trinitrate
- 1,2,3-Propanetriol, trinitrate
- Glycerol trinitrate
- Nitroglycerin
Superlist Names
- 1,2,3-Propanetriol, trinitrate
- Nitroglycerin
- Nitroglycerin mixture with >2% but not >10% nitroglycerin, by mass, desensitized
- Nitroglycerin mixture with >2% but not >10% nitroglycerin, by mass, desensitized [UN3319] [Flammable solid]
- Nitroglycerin, desensitized with not <40% non-volatile water insoluble phlegmatizer, by mass
- Nitroglycerin, desensitized with not <40% non-volatile water insoluble phlegmatizer, by mass [UN0143] [Explosive 1.1D, Poison]
- Nitroglycerin, liquid, not desensitized
- Nitroglycerin, liquid, not desensitized [Forbidden]
- Nitroglycerin, solution in alcohol with > 5% but not > 10% nitroglycerin
- Nitroglycerin, solution in alcohol, with >1% but not >10% nitroglycerin
- Nitroglycerin, solution in alcohol, with >1% but not >10% nitroglycerin [UN0144] [Explosive 1.1D]
- Nitroglycerin, solution in alcohol, with >1% but not >5% nitroglycerin
- Nitroglycerin, solution in alcohol, with >1% but not >5% nitroglycerin [UN3064] [Flammable liquid]
- Nitroglycerin, solution in alcohol, with not >1% nitroglycerin
- Nitroglycerin, solution in alcohol, with not >1% nitroglycerin [UN1204] [Flammable liquid]
- Nitroglycerine
- RCRA waste no. P081
- UN0143
- UN0144
- UN1204
- UN3064
- UN3319
Mixture Names
- SDM No. 17
- SDM No. 27
Registry Numbers
CAS Registry Number
- 55-63-0
FDA UNII
- G59M7S0WS3
Other Registry Numbers
- 100292-13-5
- 105469-31-6
- 80066-48-4
- 8013-23-8
- 9010-02-0
System Generated Number
- 0000055630
Structure Descriptors
InChI
InChI=1S/C3H5N3O9/c7-4(8)13-1-3(15-6(11)12)2-14-5(9)10/h3H,1-2H2InChIKey
SNIOPGDIGTZGOP-UHFFFAOYSA-NSmiles
[O-][N+](=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | subcutaneous | 150mg/kg (150mg/kg) | BLOOD: NORMOCYTIC ANEMIA LIVER: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 200, Pg. 271, 1942. |
| dog | LD50 | intravenous | 19mg/kg (19mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE | Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 629, 1981. |
| guinea pig | LD50 | oral | 1450mg/kg (1450mg/kg) | CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: CYANOSIS BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN | "Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 180, 1999. |
| mammal (species unspecified) | LD50 | unreported | 230mg/kg (230mg/kg) | French Demande Patent Document. Vol. #2454807, | |
| man | TDLo | intravenous | 51429ug/kg/2D (51.429mg/kg) | SENSE ORGANS AND SPECIAL SENSES: CORNEAL DAMAGE: EYE SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE BRAIN AND COVERINGS: ENCEPHALITIS | Annals of Internal Medicine. Vol. 101, Pg. 500, 1984. |
| mouse | LD50 | intraperitoneal | 104mg/kg (104mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 90, 1982. |
| mouse | LD50 | intravenous | 10600ug/kg (10.6mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 90, 1982. |
| mouse | LD50 | oral | 115mg/kg (115mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3649, 1985. |
| mouse | LD50 | skin | > 35200ug/kg (35.2mg/kg) | Drugs in Japan Vol. -, Pg. 786, 1990. | |
| mouse | LD50 | subcutaneous | 110mg/kg (110mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3649, 1985. |
| rabbit | LD50 | intraperitoneal | 189mg/kg (189mg/kg) | Drugs in Japan Vol. -, Pg. 786, 1990. | |
| rabbit | LD50 | intravenous | 45mg/kg (45mg/kg) | Drugs in Japan Vol. 6, Pg. 547, 1982. | |
| rabbit | LD50 | oral | 1607mg/kg (1607mg/kg) | Drugs in Japan Vol. -, Pg. 786, 1990. | |
| rabbit | LD50 | skin | > 280mg/kg (280mg/kg) | Drugs in Japan Vol. -, Pg. 786, 1990. | |
| rabbit | LDLo | subcutaneous | 400mg/kg (400mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 200, Pg. 271, 1942. | |
| rat | LD50 | intraperitoneal | 102mg/kg (102mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 90, 1982. | |
| rat | LD50 | intraperitoneal | 102mg/kg (102mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 90, 1982. |
| rat | LD50 | intravenous | 23200ug/kg (23.2mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | JAT, Journal of Applied Toxicology. Vol. 3, Pg. 161, 1983. |
| rat | LD50 | oral | 105mg/kg (105mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3649, 1985. |
| rat | LD50 | skin | > 29200ug/kg (29.2mg/kg) | Drugs in Japan Vol. -, Pg. 786, 1990. | |
| rat | LD50 | subcutaneous | 94mg/kg (94mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 3649, 1985. |
| women | TDLo | oral | 8ug/kg (0.008mg/kg) | CARDIAC: PULSE RATE GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: HEADACHE | American Journal of Emergency Medicine. Vol. 11, Pg. 253, 1993. |
| women | TDLo | oral | 8ug/kg (0.008mg/kg) | CARDIAC: PULSE RATE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Annals of Emergency Medicine. Vol. 23, Pg. 31, 1994. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 13.5 | deg C | EXP | |
| Boiling Point | 250 | deg C | EXP | |
| log P (octanol-water) | 1.62 | (none) | EXP | |
| Water Solubility | 1380 | mg/L | 20 | EXP |
| Henry's Law Constant | 9.87E-08 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 1.10E-12 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.