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Substance Name: Sodium dextran sulfate
RN: 9011-18-1

Notes

  • A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.
  • Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4-POSITIVE T-LYMPHOCYTES. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications.

Molecular Formula

  • H2-O4-S.x-Na.x-Unspecified

Molecular Weight

  • 468.2753
 

Classification Codes

  • Drug / Therapeutic Agent
  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Dextran sulfate sodium
  • Sodium dextran sulfate

Synonyms

  • Asuro
  • CCRIS 196
  • Dexnon
  • Dextran sodium sulfate
  • Dextran sulfate sodium salt
  • Dextrarine
  • Dexulate
  • DS-M-1
  • MDS
  • MDS (polysaccharide)
  • Sodium dextran sulfate

Systematic Names

  • Dextran sulfate sodium
  • Dextran, hydrogen sulfate, sodium salt

Registry Numbers

CAS Registry Number

  • 9011-18-1

Other Registry Numbers

  • 207464-10-6
  • 50935-35-8
  • 57972-02-8

System Generated Number

  • 0009011181

Molecular Formulas

Molecular Formula

  • H2-O4-S.x-Na.x-Unspecified

Molecular Formula Fragments

  • COMPONENT
  • H2-O4-S
  • Na
  • Unspecified

Structure Descriptors

Smiles

O1[C@@H]([C@@H](OS(=O)([O-])=O)[C@@H]([C@H]([C@H]1O*)OS(=O)([O-])=O)OS([O-])(=O)=O)C*.[Na+].[Na+].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 2350mg/kg (2350mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1318, 1979.
mouse LD50 oral 25200mg/kg (25200mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1318, 1979.
rabbit LD50 intravenous 19gm/kg (19000mg/kg)   Drugs in Japan Vol. 6, Pg. 481, 1982.
rat LD50 intravenous 473mg/kg (473mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1318, 1979.
rat LD50 oral 20600mg/kg (20600mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1318, 1979.