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Substance Name: Lysostaphin [USAN]
RN: 9011-93-2
UNII: 63R7TZH0UA

Note

  • A 25-kDa peptidase produced by Staphylococcus simulans which cleaves a glycine-glcyine bond unique to an inter-peptide cross-bridge of the STAPHYLOCOCCUS AUREUS cell wall. EC 3.4.24.75.
 

Classification Codes

  • Anti-Infective Agents
  • Anti-Infective Agents, Local
  • Antibacterial Enzyme
  • Natural Product
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Names and Synonyms

Name of Substance

  • Lysostaphin [USAN]

MeSH Heading

  • Lysostaphin

Synonyms

  • Lysostaphin
  • UNII-63R7TZH0UA

Systematic Name

  • Lysostaphin

Registry Numbers

CAS Registry Number

  • 9011-93-2

FDA UNII

  • 63R7TZH0UA

System Generated Number

  • 0009011932

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 820mg/kg (820mg/kg)   "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 887, 1989.
rat LD50 intravenous 530mg/kg (530mg/kg)   "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 887, 1989.