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Substance Name: Fostamatinib [USAN:INN]
RN: 901119-35-5
UNII: SQ8A3S5101
InChIKey: GKDRMWXFWHEQQT-UHFFFAOYSA-N

Note

  • A spleen tyrosine kinase (Syk) inhibitor, metabolized to R406.

Classification Codes

  • Antiviral (COVID-19)
  • Treatment of Rheumatoid Arthritis, Immune Thrombocytopenic Purpura, and B-Cell Lymphoma

Molecular Formula

  • C23-H26-F-N6-O9-P

Molecular Weight

  • 580.4634
 
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Names and Synonyms

Name of Substance

  • Fostamatinib
  • Fostamatinib [USAN:INN]

Synonyms

  • Fostamatinib
  • R 788
  • R 788 compound
  • R788
  • R788 compound
  • R788 free acid
  • R935788 free acid
  • Tavalisse
  • UNII-SQ8A3S5101

Systematic Name

  • 2H-Pyrido(3,2-b)-1,4-oxazin-3(4H)-one, 6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)-4-pyrimidinyl)amino)-2,2-dimethyl-4-((phosphonooxy)methyl)-

Registry Numbers

CAS Registry Number

  • 901119-35-5

FDA UNII

  • SQ8A3S5101

Other Registry Number

  • 945745-48-2

System Generated Number

  • 0901119355

Structure Descriptors

InChI

InChI=1S/C23H26FN6O9P/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29)

InChIKey

GKDRMWXFWHEQQT-UHFFFAOYSA-N

Smiles

COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)N(COP(=O)(O)O)c4n3)n2)cc(OC)c1OC