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Substance Name: Cholera toxin
RN: 9012-63-9

Note

  • An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Adjuvants, Immunologic
  • Immunologic Factors
  • Mutation Data
  • Natural Product
  • Noxae
  • Poisons
  • Reproductive Effect
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Links to Resources

Names and Synonyms

Name of Substance

  • Cholera toxin

MeSH Heading

  • Cholera toxin

Synonyms

  • Cholera entero-exotoxin
  • Cholera enterotoxin
  • Cholera exotoxin
  • Cholera toxin
  • Cholera toxin (Vibrio cholerae & Vibrio mimicus)
  • Choleragen
  • exo-Enterotoxin
  • Vibrio cholerae exotoxin

Systematic Names

  • Exotoxin, vibrio cholerae
  • Toxins, cholera

Registry Numbers

CAS Registry Number

  • 9012-63-9

System Generated Number

  • 0009012639

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LDLo intravenous 10ug/kg (0.01mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: FOOD INTAKE (ANIMAL)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicon. Vol. 18, Pg. 309, 1980.
mouse LD50 intravenous 260ug/kg (0.26mg/kg)   Immunological Communications. Vol. 1, Pg. 223, 1972.
rabbit LDLo intravenous 100ug/kg (0.1mg/kg)   Toxicon. Vol. 19, Pg. 701, 1981.