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Substance Name: Asparaginase [USAN]
RN: 9015-68-3
UNII: G4FQ3CKY5R

Note

  • A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Natural Product
  • Reproductive Effect
  • Tumor Data

Names and Synonyms

Name of Substance

  • Asparaginase [USAN]
  • L-Asparaginase

MeSH Heading

  • Asparaginase

Synonyms

  • Acrylaway L
  • alpha-Asparaginase
  • Asparaginase
  • Asparaginase medac
  • Asparaginase, L- (Escherichia coli)
  • Colaspase
  • Crasnitin
  • Crasnitine
  • E. C. 3.5.1.1
  • EC 2
  • EINECS 232-765-3
  • Elspar
  • HSDB 8012
  • Kidrolase
  • L-Asnase
  • L-Asparagin-amidohydrolase
  • L-Asparaginase
  • L-Asparaginase (Immobilized)
  • L-Asparaginase from Escherichia coli
  • L-Asparaginase X
  • L-Asparaginasi
  • L-Asparaginasi [Italian]
  • L-Asparagine amidohydrolase
  • Leunase
  • MK 965
  • MK-965
  • NSC 109229
  • NSC-109229
  • Oncospar
  • Paronal
  • Preventase M
  • Re 82-Tad-15
  • UNII-G4FQ3CKY5R

Systematic Names

  • Asparaginase
  • L-Asparaginase

Registry Numbers

CAS Registry Number

  • 9015-68-3

FDA UNII

  • G4FQ3CKY5R

Other Registry Numbers

  • 9037-33-6
  • 9037-34-7
  • 9060-77-9

System Generated Number

  • 0009015683

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 227mg/kg (227mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: NAUSEA OR VOMITING
Recent Results in Cancer Research. Vol. 33, Pg. 174, 1970.
child TDLo intramuscular 8145iu/kg/1W (8145iu/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS Cancer Vol. 34, Pg. 780, 1974.
dog LD50 intravenous 227mg/kg (227mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: NAUSEA OR VOMITING
Recent Results in Cancer Research. Vol. 33, Pg. 174, 1970.
guinea pig LD50 intraperitoneal 11662mg/kg (11662mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.
mouse LD50 intraperitoneal 334gm/kg (334000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.
mouse LD50 intravenous 136gm/kg (136000mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.
mouse LD50 oral 5000ku/kg (5000000iu/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 13, Pg. 919, 1971.
mouse LD50 subcutaneous 345gm/kg (345000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.
rabbit LD50 intravenous 2273ug/kg (2.273mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.
rat LD50 intraperitoneal 8204mg/kg (8204mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.
rat LD50 intravenous 7568mg/kg (7568mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.
rat LD50 oral 7500ku/kg (7500000iu/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 13, Pg. 919, 1971.
rat LD50 subcutaneous 8204mg/kg (8204mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.