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Substance Name: Hypoxanthine Phosphoribosyltransferase
RN: 9016-12-0

Note

  • An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or 6-mercaptopurine to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.
 
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Names and Synonyms

Name of Substance

  • Hypoxanthine Phosphoribosyltransferase

MeSH Heading

  • Hypoxanthine Phosphoribosyltransferase

Synonyms

  • Guanine phosphoribosyltransferase
  • HGPRT
  • HPRT
  • HPRTase
  • Hypoxanthine guanine phosphoribosyltransferase
  • Hypoxanthine-guanine phosphoribosyltransferase
  • IMP Pyrophosphorylase
  • Phosphoribosyltransferase, guanine
  • Phosphoribosyltransferase, hypoxanthine
  • Phosphoribosyltransferase, hypoxanthine-guanine
  • Pyrophosphorylase, IMP

Systematic Name

  • IMP:pyrophosphate phospho-D-ribosyltransferase

Registry Numbers

CAS Registry Number

  • 9016-12-0

System Generated Number

  • 0009016120