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Substance Name: Antithrombin III human [USP]
RN: 9000-94-6
UNII: T0LTO7L82X

Note

  • A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Anticoagulants
  • Antithrombins
  • Enzyme Inhibitors
  • Hematologic Agents
  • Protease Inhibitors
  • Reproductive Effect
  • Serine Proteinase Inhibitors

Names and Synonyms

Name of Substance

  • Antithrombin III human [USP]
  • Antithrombin III [INN:BAN]
  • Antraformin

MeSH Heading

  • Antithrombin III

Synonyms

  • Antithrombin III
  • Antithrombin III (human)
  • Antithrombin iii human
  • AT-III
  • Atenativ
  • BI 6013
  • EINECS 232-568-2
  • Heparin cofactor
  • Heparin cofactor B
  • Kybernin
  • Neuart
  • Org 10849
  • Serpin C1
  • THROMBATE III
  • Thrombin inhibitor
  • UNII-T0LTO7L82X

Systematic Names

  • Antithrombin
  • Antithrombin III

Registry Numbers

CAS Registry Number

  • 9000-94-6

FDA UNII

  • T0LTO7L82X

Other Registry Numbers

  • 52014-67-2
  • 90170-80-2
  • 9041-91-2

System Generated Number

  • 0009000946

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous > 6ku/kg (6000iu/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 677, 1986.
mouse LD50 intravenous > 15ku/kg (15000iu/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 677, 1986.
mouse LD50 oral > 15ku/kg (15000iu/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 677, 1986.
mouse LD50 subcutaneous > 20ku/kg (20000iu/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 677, 1986.
rat LD50 intravenous > 15ku/kg (15000iu/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 677, 1986.
rat LD50 oral > 15ku/kg (15000iu/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 677, 1986.
rat LD50 subcutaneous > 20ku/kg (20000iu/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 677, 1986.