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Substance Name: Formate-Tetrahydrofolate Ligase
RN: 9023-66-9


  • A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate in the presence of ATP. In higher eukaryotes the enzyme also contains METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+) and METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE activity.
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Names and Synonyms

Name of Substance

  • Formate-Tetrahydrofolate Ligase

MeSH Heading

  • Formate-Tetrahydrofolate Ligase


  • Formate tetrahydrofolate ligase
  • Formylase, tetrahydrofolate
  • Formyltetrahydrofolate synthetase
  • Ligase, formate-tetrahydrofolate
  • Synthetase, formyltetrahydrofolate
  • Tetrahydrofolate formylase

Systematic Name

  • Formate:tetrahydrofolate ligase (ADP-forming)

Registry Numbers

CAS Registry Number

  • 9023-66-9

System Generated Number

  • 0009023669