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Substance Name: Montirelin [INN]
RN: 90243-66-6
UNII: 30MUJ6YYUY
InChIKey: RSHMQGIMHQPMEB-IXOXFDKPSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C17-H24-N6-O4-S

Molecular Weight

  • 408.4806
 
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Names and Synonyms

Name of Substance

  • Montirelin [INN]

Synonyms

  • (-)-N-(((3R,6S)-6-Methyl-5-oxo-3-thiomorpholinyl)carbonyl)-L-histidyl-L-prolinamide
  • (3R-cis)-N-((6-Methyl-5-oxo-3-thiomorpholinyl)carbonyl)-L-histidyl-L-prolinamide
  • CCRIS 7571
  • CG 3703
  • CNK 602A
  • CNK-603
  • L-Prolinamide, (2R)-2-mercaptopropanoyl-L-cysteinyl-L-histidyl-, cyclic (1-2)-sulfide
  • Montirelin
  • Montirelina
  • Montirelina [Spanish]
  • Montireline
  • Montireline [French]
  • Montirelinum
  • Montirelinum [Latin]
  • N-(((3R,6R)-6-Methyl-5-oxo-3-thiomorpholinyl)carbonyl)-L-histidyl-L-prolinamide
  • NS 3
  • UNII-30MUJ6YYUY

Systematic Names

  • L-Prolinamide, (3R,6R)-6-methyl-5-oxo-3-thiomorpholinecarbonyl-L-histidyl-
  • L-Prolinamide, N-((6-methyl-5-oxo-3-thiomorpholinyl)carbonyl)-L-histidyl-, (3R-cis)-
  • Montirelin
  • N-(((3R,6R)-6-Methyl-5-oxo-3-thiomorpholinyl)carbonyl)-L-histidyl-L-prolinamide

Registry Numbers

CAS Registry Number

  • 90243-66-6

FDA UNII

  • 30MUJ6YYUY

System Generated Number

  • 0090243666

Structure Descriptors

InChI

1S/C17H24N6O4S/c1-9-15(25)22-12(7-28-9)16(26)21-11(5-10-6-19-8-20-10)17(27)23-4-2-3-13(23)14(18)24/h6,8-9,11-13H,2-5,7H2,1H3,(H2,18,24)(H,19,20)(H,21,26)(H,22,25)/t9-,11+,12+,13+/m1/s1

InChIKey

RSHMQGIMHQPMEB-IXOXFDKPSA-N

Smiles

C[C@H]1SC[C@H](NC1=O)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N3CCC[C@H]3C(=O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD oral > 5gm/kg (5000mg/kg)   United States Patent Document. Vol. #4877784,
mouse LDLo intravenous 125mg/kg (125mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Journal of Toxicological Sciences. Vol. 20(Suppl,