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Substance Name: Oxygenase, protocollagen proline di-
RN: 9028-06-2


  • A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl containing peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.
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Names and Synonyms

MeSH Heading

  • Procollagen-Proline Dioxygenase


  • Protocollagen hydroxylase
  • Protocollagen proline dioxygenase

Systematic Name

  • Oxygenase, protocollagen proline di-

Registry Numbers

CAS Registry Number

  • 9028-06-2

System Generated Number

  • 0009028062