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Substance Name: 2-Isopropylmalate Synthase
RN: 9030-98-2


  • An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE, forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. This enzyme was formerly listed as EC
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Names and Synonyms

Name of Substance

  • 2-Isopropylmalate Synthase

MeSH Heading

  • 2-Isopropylmalate Synthase


  • 2 Isopropylmalate Synthase
  • alpha Isopropylmalate Synthase
  • alpha-Isopropylmalate Synthase
  • Synthase, 2-Isopropylmalate
  • Synthase, alpha-Isopropylmalate

Systematic Name

  • 3-Carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating)

Registry Numbers

CAS Registry Number

  • 9030-98-2

System Generated Number

  • 0009030982