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Substance Name: Reductase, cycochrome b5
RN: 9032-25-1


  • A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.
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Names and Synonyms

MeSH Heading

  • Cytochrome-B(5) Reductase


  • NADH-cytochrome b5 reductase

Systematic Name

  • Reductase, cycochrome b5

Registry Numbers

CAS Registry Number

  • 9032-25-1

System Generated Number

  • 0009032251