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Substance Name: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
RN: 9033-23-2


  • An enzyme that catalyzes the formation of methionine by transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine. It requires a cobamide coenzyme. The enzyme can act on mono- or triglutamate derivatives. EC
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Names and Synonyms

Name of Substance

  • 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase

MeSH Heading

  • 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase


  • Homocysteine Methyltransferase, Methyltetrahydrofolate
  • Methionine Synthase
  • Methionine Synthetase
  • Methyltetrahydrofolate Homocysteine Methyltransferase
  • Methyltransferase, Methyltetrahydrofolate Homocysteine
  • Methyltransferase, Tetrahydropteroylglutamate
  • S-Methyltransferase, 5-Methyltetrahydrofolate-Homocysteine
  • Synthase, Methionine
  • Synthetase, Methionine
  • Tetrahydropteroylglutamate Methyltransferase
  • Vitamin B12-Dependent Methionine Synthase
  • Vitamin B12-Independent Methionine Synthase

Systematic Name

  • 5-Methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase

Registry Numbers

CAS Registry Number

  • 9033-23-2

System Generated Number

  • 0009033232