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Substance Name: Somatotropin-releasing hormone
RN: 9034-39-3
InChIKey: JHAWGIGALHWDNA-XXWMTRDNSA-N

Note

  • A peptide of 44 amino acids in most species that stimulates the release and synthesis of GROWTH HORMONE. GHRF (or GRF) is synthesized by neurons in the ARCUATE NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, GHRF stimulates GH release by the SOMATOTROPHS in the PITUITARY GLAND.

Molecular Formula

  • Unspecified

Molecular Weight

  • 12447.3767
 

Classification Codes

  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
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Names and Synonyms

Name of Substance

  • Somatotropin-releasing hormone

MeSH Heading

  • Growth hormone-releasing hormone

Synonyms

  • GRF-(1-44) amide
  • Growth hormone releasing factor
  • Growth hormone-releasing factor
  • Growth hormone-releasing factor 44
  • Growth hormone-releasing hormone
  • Somatocrinin
  • Somatotropin releasing hormone
  • Somatotropin-releasing factor 44
  • Somatotropin-releasing hormone

Systematic Name

  • Somatoliberin

Registry Numbers

CAS Registry Number

  • 9034-39-3

System Generated Number

  • 0009034393

Structure Descriptors

InChI

1S/C546H883N165O156S6/c1-62-280(43)426(700-439(771)290(53)614-478(810)373(234-417(757)758)652-437(769)288(51)612-476(808)359(224-298-138-142-304(727)143-139-298)659-456(788)324(131-99-194-599-545(584)585)629-449(781)320(127-95-190-595-541(576)577)630-470(802)341(177-202-870-58)647-452(784)322(129-97-192-597-543(580)581)631-482(814)354(215-270(23)24)676-528(860)430(291(54)724)704-499(831)356(217-272(27)28)672-518(850)390-134-102-197-708(390)533(865)392-136-104-199-710(392)535(867)393-137-105-200-711(393)534(866)391-135-103-198-709(391)532(864)387(257-723)693-516(848)388(258-868)694-492(824)368(229-303-240-589-260-609-303)666-511(843)384(254-720)692-514(846)385(255-721)690-495(827)371(232-406(564)741)669-513(845)383(253-719)686-487(819)355(216-271(25)26)677-529(861)431(292(55)725)705-500(832)358(219-274(31)32)675-527(859)429(283(46)65-4)703-523(855)425(279(41)42)699-501(833)363(222-296-110-74-68-75-111-296)661-489(821)360(220-294-106-70-66-71-107-294)660-490(822)362(221-295-108-72-67-73-109-295)678-521(853)424(278(39)40)698-503(835)366(227-301-238-602-310-117-81-79-115-307(301)310)664-485(817)353(214-269(21)22)671-517(849)389-133-101-196-707(389)531(863)308(551)176-201-869-57)525(857)679-364(223-297-112-76-69-77-113-297)502(834)706-432(293(56)726)530(862)680-372(233-407(565)742)496(828)689-382(252-718)510(842)662-361(225-299-140-144-305(728)145-141-299)488(820)632-321(128-96-191-596-542(578)579)450(782)628-316(121-85-89-184-550)474(806)695-422(276(35)36)520(852)673-346(207-262(7)8)444(776)606-244-411(746)618-328(148-163-396(554)731)458(790)655-352(213-268(19)20)486(818)685-376(246-712)505(837)615-287(50)435(767)621-318(125-93-188-593-539(572)573)448(780)625-314(119-83-87-182-548)453(785)654-351(212-267(17)18)484(816)658-350(211-266(15)16)481(813)644-335(154-169-402(560)737)467(799)670-375(236-419(761)762)504(836)701-427(281(44)63-2)524(856)650-344(180-205-873-61)473(805)683-377(247-713)506(838)633-323(130-98-193-598-544(582)583)451(783)638-331(150-165-398(556)733)462(794)635-326(146-161-394(552)729)441(773)604-242-410(745)619-329(156-171-412(747)748)459(791)682-381(251-717)512(844)668-369(230-404(562)739)493(825)645-334(153-168-401(559)736)463(795)641-338(158-173-414(751)752)466(798)624-311(122-90-185-590-536(566)567)440(772)603-241-408(743)610-284(47)433(765)620-317(124-92-187-592-538(570)571)445(777)611-285(48)434(766)622-319(126-94-189-594-540(574)575)455(787)653-345(206-261(5)6)443(775)605-243-409(744)617-312(123-91-186-591-537(568)569)446(778)640-336(155-170-403(561)738)475(807)696-423(277(37)38)522(854)681-374(235-418(759)760)497(829)691-380(250-716)509(841)649-343(179-204-872-60)472(804)663-365(226-300-237-601-309-116-80-78-114-306(300)309)477(809)613-286(49)436(768)623-337(157-172-413(749)750)465(797)639-330(149-164-397(555)732)460(792)626-313(118-82-86-181-547)447(779)637-332(151-166-399(557)734)464(796)648-342(178-203-871-59)471(803)642-339(159-174-415(753)754)468(800)656-348(209-264(11)12)479(811)646-340(160-175-416(755)756)469(801)684-386(256-722)515(847)702-428(282(45)64-3)526(858)674-357(218-273(29)30)498(830)697-421(275(33)34)519(851)616-289(52)438(770)651-347(208-263(9)10)483(815)657-349(210-265(13)14)480(812)643-333(152-167-400(558)735)461(793)627-315(120-84-88-183-549)454(786)665-367(228-302-239-588-259-608-302)491(823)687-378(248-714)507(839)634-325(132-100-195-600-546(586)587)457(789)667-370(231-405(563)740)494(826)688-379(249-715)508(840)636-327(147-162-395(553)730)442(774)607-245-420(763)764/h66-81,106-117,138-145,237-240,259-293,308,311-393,421-432,601-602,712-728,868H,62-65,82-105,118-137,146-236,241-258,547-551H2,1-61H3,(H2,552,729)(H2,553,730)(H2,554,731)(H2,555,732)(H2,556,733)(H2,557,734)(H2,558,735)(H2,559,736)(H2,560,737)(H2,561,738)(H2,562,739)(H2,563,740)(H2,564,741)(H2,565,742)(H,588,608)(H,589,609)(H,603,772)(H,604,773)(H,605,775)(H,606,776)(H,607,774)(H,610,743)(H,611,777)(H,612,808)(H,613,809)(H,614,810)(H,615,837)(H,616,851)(H,617,744)(H,618,746)(H,619,745)(H,620,765)(H,621,767)(H,622,766)(H,623,768)(H,624,798)(H,625,780)(H,626,792)(H,627,793)(H,628,782)(H,629,781)(H,630,802)(H,631,814)(H,632,820)(H,633,838)(H,634,839)(H,635,794)(H,636,840)(H,637,779)(H,638,783)(H,639,797)(H,640,778)(H,641,795)(H,642,803)(H,643,812)(H,644,813)(H,645,825)(H,646,811)(H,647,784)(H,648,796)(H,649,841)(H,650,856)(H,651,770)(H,652,769)(H,653,787)(H,654,785)(H,655,790)(H,656,800)(H,657,815)(H,658,816)(H,659,788)(H,660,822)(H,661,821)(H,662,842)(H,663,804)(H,664,817)(H,665,786)(H,666,843)(H,667,789)(H,668,844)(H,669,845)(H,670,799)(H,671,849)(H,672,850)(H,673,852)(H,674,858)(H,675,859)(H,676,860)(H,677,861)(H,678,853)(H,679,857)(H,680,862)(H,681,854)(H,682,791)(H,683,805)(H,684,801)(H,685,818)(H,686,819)(H,687,823)(H,688,826)(H,689,828)(H,690,827)(H,691,829)(H,692,846)(H,693,848)(H,694,824)(H,695,806)(H,696,807)(H,697,830)(H,698,835)(H,699,833)(H,700,771)(H,701,836)(H,702,847)(H,703,855)(H,704,831)(H,705,832)(H,706,834)(H,747,748)(H,749,750)(H,751,752)(H,753,754)(H,755,756)(H,757,758)(H,759,760)(H,761,762)(H,763,764)(H4,566,567,590)(H4,568,569,591)(H4,570,571,592)(H4,572,573,593)(H4,574,575,594)(H4,576,577,595)(H4,578,579,596)(H4,580,581,597)(H4,582,583,598)(H4,584,585,599)(H4,586,587,600)/t280-,281-,282-,283-,284-,285-,286-,287-,288-,289-,290-,291+,292+,293+,308-,311-,312-,313-,314-,315-,316-,317-,318-,319-,320-,321-,322-,323-,324-,325-,326-,327-,328-,329-,330-,331-,332-,333-,334-,335-,336-,337-,338-,339-,340-,341-,342-,343-,344-,345-,346-,347-,348-,349-,350-,351-,352-,353-,354-,355-,356-,357-,358-,359-,360-,361-,362-,363-,364-,365-,366-,367-,368-,369-,370-,371-,372-,373-,374-,375-,376-,377-,378-,379-,380-,381-,382-,383-,384-,385-,386-,387-,388-,389-,390-,391-,392-,393-,421-,422-,423-,424-,425-,426-,427-,428-,429-,430-,431-,432-/m0/s1

InChIKey

JHAWGIGALHWDNA-XXWMTRDNSA-N

Smiles

CC[C@H](C)[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc2ccc(cc2)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc3c[nH]c4c3cccc4)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc5cnc[nH]5)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](Cc6ccc(cc6)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]7CCCN7C(=O)[C@@H]8CCCN8C(=O)[C@@H]9CCCN9C(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCSC)N