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Substance Name: Proinsulin
RN: 9035-68-1

Note

  • A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.

Molecular Formula

  • Unspecified
 
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Names and Synonyms

Name of Substance

  • Proinsulin

MeSH Heading

  • Proinsulin

Synonym

  • Proinsulin

Systematic Name

  • Proinsulin

Registry Numbers

CAS Registry Number

  • 9035-68-1

System Generated Number

  • 0009035681