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Substance Name: 5-Aminolevulinate Synthetase
RN: 9037-14-3


  • An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC
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Names and Synonyms

Name of Substance

  • 5-Aminolevulinate Synthetase

MeSH Heading

  • 5-Aminolevulinate Synthetase


  • 5 Aminolevulinate Synthase
  • 5 Aminolevulinate Synthetase
  • 5-Aminolevulinate Synthase
  • Acid Synthetase, Aminolevulinic
  • Acid Synthetase, delta-Aminolevulinic
  • Aminolevulinic Acid Synthetase
  • delta Aminolevulinate Synthase
  • delta Aminolevulinic Acid Synthetase
  • delta-Aminolevulinate Synthase
  • delta-Aminolevulinic Acid Synthetase
  • Synthase, 5-Aminolevulinate
  • Synthase, delta-Aminolevulinate
  • Synthetase, 5-Aminolevulinate
  • Synthetase, Aminolevulinic Acid
  • Synthetase, delta-Aminolevulinic Acid

Systematic Name

  • Succinyl-CoA:glycine C-Succinyltransferase (decarboxylating)

Registry Numbers

CAS Registry Number

  • 9037-14-3

System Generated Number

  • 0009037143