Substance Name: Urokinase [USAN:INN:BAN:JAN]
RN: 9039-53-6
UNII: 83G67E21XI
Note
- A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES.
Molecular Formula
- Unspecified
Classification Codes
- Drug / Therapeutic Agent
- Plasminogen Activator
- Plasminogen Activators
- Reproductive Effect
- TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
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Names and Synonyms
Name of Substance
- Urokinase
- Urokinase [USAN:INN:BAN:JAN]
MeSH Heading
- Urokinase-Type Plasminogen Activator
Synonyms
- Abbokinase
- Actosolv
- Breokinase
- E.C. 3.4.21.31
- E.C. 3.4.21.73
- E.C. 3.4.99.26
- EINECS 232-917-9
- Kinase (enzyme-activating), uro-urokinase
- Kinlytic
- Plasminokinase, urinary
- TCUK
- Tissue culture urokinase
- Two-chain urokinase
- UK
- Ukidan
- UNII-83G67E21XI
- Urochinasi
- Urochinasi [DCIT]
- Urokinase
- Urokinasum
- Urokinasum [INN-Latin]
- Uroquinasa
- Uroquinasa [INN-Spanish]
- WIN 22005
- Win-Kinase
Systematic Names
- Kinase (enzyme-activating), uro-
- Urokinase (peptidolytic)
Registry Numbers
CAS Registry Number
- 9039-53-6
FDA UNII
- 83G67E21XI
Other Registry Numbers
- 139639-24-0
- 37211-64-6
System Generated Number
- 0009039536
Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | > 909ug/kg (0.909mg/kg) | Drugs in Japan Vol. -, Pg. 164, 1990. | |
| mouse | LD50 | intravenous | > 3000ku/kg (3000000iu/kg) | Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 514, 1981. | |
| mouse | LD50 | oral | > 2727ug/kg (2.727mg/kg) | Drugs in Japan Vol. -, Pg. 164, 1990. | |
| mouse | LD50 | subcutaneous | > 2727ug/kg (2.727mg/kg) | Drugs in Japan Vol. -, Pg. 164, 1990. | |
| rat | LD50 | intravenous | > 3000ku/kg (3000000iu/kg) | Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 514, 1981. | |
| rat | LD50 | oral | > 2727ug/kg (2.727mg/kg) | Drugs in Japan Vol. -, Pg. 164, 1990. | |
| rat | LD50 | subcutaneous | > 2727ug/kg (2.727mg/kg) | Drugs in Japan Vol. -, Pg. 164, 1990. |