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Substance Name: Urokinase [USAN:INN:BAN:JAN]
RN: 9039-53-6
UNII: 83G67E21XI

Note

  • A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Drug / Therapeutic Agent
  • Plasminogen Activator
  • Plasminogen Activators
  • Reproductive Effect
  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
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Names and Synonyms

Name of Substance

  • Urokinase
  • Urokinase [USAN:INN:BAN:JAN]

MeSH Heading

  • Urokinase-Type Plasminogen Activator

Synonyms

  • Abbokinase
  • Actosolv
  • Breokinase
  • E.C. 3.4.21.31
  • E.C. 3.4.21.73
  • E.C. 3.4.99.26
  • EINECS 232-917-9
  • Kinase (enzyme-activating), uro-urokinase
  • Kinlytic
  • Plasminokinase, urinary
  • TCUK
  • Tissue culture urokinase
  • Two-chain urokinase
  • UK
  • Ukidan
  • UNII-83G67E21XI
  • Urochinasi
  • Urochinasi [DCIT]
  • Urokinase
  • Urokinasum
  • Urokinasum [INN-Latin]
  • Uroquinasa
  • Uroquinasa [INN-Spanish]
  • WIN 22005
  • Win-Kinase

Systematic Names

  • Kinase (enzyme-activating), uro-
  • Urokinase (peptidolytic)

Registry Numbers

CAS Registry Number

  • 9039-53-6

FDA UNII

  • 83G67E21XI

Other Registry Numbers

  • 139639-24-0
  • 37211-64-6

System Generated Number

  • 0009039536

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous > 909ug/kg (0.909mg/kg)   Drugs in Japan Vol. -, Pg. 164, 1990.
mouse LD50 intravenous > 3000ku/kg (3000000iu/kg)   Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 514, 1981.
mouse LD50 oral > 2727ug/kg (2.727mg/kg)   Drugs in Japan Vol. -, Pg. 164, 1990.
mouse LD50 subcutaneous > 2727ug/kg (2.727mg/kg)   Drugs in Japan Vol. -, Pg. 164, 1990.
rat LD50 intravenous > 3000ku/kg (3000000iu/kg)   Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 514, 1981.
rat LD50 oral > 2727ug/kg (2.727mg/kg)   Drugs in Japan Vol. -, Pg. 164, 1990.
rat LD50 subcutaneous > 2727ug/kg (2.727mg/kg)   Drugs in Japan Vol. -, Pg. 164, 1990.