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Substance Name: Heparin sodium [USP:INN:BAN:JAN]
RN: 9041-08-1

Note

  • A low molecualr weight heparin from Wyeth; a depolymerized porcine mucosal heparin; mean MW 5-6 kDa.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Anticoagulant
  • Anticoagulants
  • Antithrombotic
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Fibrin Modulating Agents
  • Fibrinolytic Agents
  • Hematologic Agents
  • Human Data
  • Treatment of Inflammatory Bowel Disease
  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)

Names and Synonyms

Results Name

  • Heparin sodium [USP:INN:BAN:JAN]

Name of Substance

  • Adomiparin sodium [USAN:INN]
  • Ardeparin sodium [USAN:INN]
  • Bemiparin sodium [INN]
  • Certoparin sodium [INN]
  • Dalteparin sodium
  • Dalteparin sodium [USAN:INN:BAN]
  • Deligoparin sodium [USAN:INN]
  • Enoxaparin sodium [USAN:INN]
  • Heparin sodium
  • Heparin sodium [USP:INN:BAN:JAN]
  • Parnaparin sodium [INN]
  • Reviparin sodium [INN]
  • Semuloparin sodium [USAN:INN]
  • Sevuparin sodium [INN]
  • Tinzaparin sodium
  • Tinzaparin sodium [USAN:INN:BAN]

Synonyms

  • Adomiparin sodium
  • ALFA 87-120
  • ALFA 87-163
  • ALFA 87-198
  • ALFA 87-81
  • ALFA 88-247
  • Ardeparin sodium
  • AVE 5026
  • AVE-5026
  • AVE5026
  • Bemiparin sodium
  • Certoparin sodium
  • Dalteparin sodium
  • Deligoparin sodium
  • Depo-Heparin
  • Depolymerized heparin obtained by peroxide fragmentation of heparin sodium (USP). The end chain structure appears to be the same as the starting material with no unusual sugar residues present. The low molecular weight heparin produced differs from the starting material in molecular weight only. The average relative molecular mass range is 5,500 to 6,500 daltons, with not less than 98 percent, by weight, of the compounds between 2,000 and 15,000 daltons. The degree of sulfation is approximately 2.7 sulfate residues per disaccharide unit. The substance is the sodium salt
  • Enoxaparin sodium
  • Fragmin
  • Fragmin IV
  • Fragmin P Forte
  • H 2149
  • Hed-heparin
  • Hep Flush Kit in plastic container
  • Hep-Lock
  • Hep-Lock U/P
  • Hepamax-S
  • Heparin Fragment Kabi 2165
  • Heparin Lock Flush
  • Heparin Lock Flush in plastic container
  • Heparin Lock Flush preservative free
  • Heparin Lock Flush preservative free in plastic container
  • Heparin natrium
  • Heparin sodium
  • Heparin sodium 1,000 units and sodium chloride 0.9% in plastic container
  • Heparin sodium 1,000 units in dextrose 5% in plastic container
  • Heparin sodium 1,000 units in sodium chloride 0.9% in plastic container
  • Heparin sodium 10,000 units in dextrose 5%
  • Heparin sodium 10,000 units in dextrose 5% in plastic container
  • Heparin sodium 10,000 units in sodium chloride 0.45%
  • Heparin sodium 10,000 units in sodium chloride 0.9%
  • Heparin sodium 12,500 units in dextrose 5%
  • Heparin sodium 12,500 units in dextrose 5% in plastic container
  • Heparin sodium 12,500 units in sodium chloride 0.45% in plastic container
  • Heparin sodium 12,500 units in sodium chloride 0.9%
  • Heparin sodium 2,000 units and sodium chloride 0.9% in plastic container
  • Heparin sodium 2,000 units in dextrose 5% in plastic container
  • Heparin sodium 2,000 units in sodium chloride 0.9% in plastic container
  • Heparin sodium 20,000 units and dextrose 5% in plastic container
  • Heparin sodium 20,000 units in dextrose 5% in plastic container
  • Heparin sodium 25,000 units and dextrose 5% in plastic container
  • Heparin sodium 25,000 units in dextrose 5%
  • Heparin sodium 25,000 units in dextrose 5% in plastic container
  • Heparin sodium 25,000 units in sodium chloride 0.45% in plastic container
  • Heparin sodium 25,000 units in sodium chloride 0.9%
  • Heparin sodium 25,000 units in sodium chloride 0.9% in plastic container
  • Heparin sodium 5,000 units and sodium chloride 0.9% in plastic container
  • Heparin sodium 5,000 units in dextrose 5% in plastic container
  • Heparin sodium 5,000 units in sodium chloride 0.45%
  • Heparin sodium 5,000 units in sodium chloride 0.9%
  • Heparin sodium 5,000 units in sodium chloride 0.9% in plastic container
  • Heparin sodium in plastic container
  • Heparin sodium preservative free
  • Heparin, sodium salt. Molecular weight is approximately 3200 daltons +- 650 daltons
  • Heparinum natricum
  • Hepathrom
  • Hepflush-10
  • Inno-Hep
  • Innohep
  • Kabi 2165
  • LHN 1
  • Lioton 1000
  • Lipo-hepin
  • Liquaemin Lock Flush
  • Liquaemin Sodium
  • Liquaemin sodium preservative free
  • Liquemin
  • Logiparin
  • Lovenox Injection (as the base)
  • M 118 sodium
  • M118
  • Minolteparin sodium
  • Normiflo
  • OP2000
  • Panheprin
  • Parnaparin sodium
  • PK 10169
  • Pularin
  • Reviparin sodium
  • RO 11
  • RP 54563
  • Semuloparin sodium
  • Sevuparin sodium
  • Sodium acid heparin
  • Sodium heparin
  • Sodium heparinate
  • Sodium salt of depolymerized heparin obtained by alkaline degradation of quaternary ammonium salt of heparin from pork intestinal mucosa; the majority of the components have a 2-O-sulfo-4-enepyranosuronic acid structure at the non-reducing end and a 2-N,6-O-disulfo-D-glucosamine structure at the reducing end of their chain; the average relative molecular mass is about 3600 (3000 to 4200); the degree of sulfatation is about 2 per disaccharidic unit
  • Sodium salt of depolymerized heparin obtained by heparinase from Flavobacterium heparinum (heparin lyase: EC 4.2.2.7) degradation of heparin from pork intestinal mucosa. The majority of the components have a 2-O-sulfo-4-enepyranosuronic acid structure at the non-reducing end and a 2-N:6-O-disulfo-D-glucosamine structure at the reducing end of their chain. The relative molecular mass is 4500 +- 1500, 70 percent of which ranges between 1500 and 10,000. The degree of sulfation is 2 to 2.5 per disaccharide unit
  • Sodium salt of depolymerized heparin obtained by nitrous acid degradation of heparin from pork intestinal mucosa. The majority of the components have a 2-O-sulfo-alpha-L-idopyranosuronic acid structure at the non-reducing end and a 6-O-sulfo-2,5-anhydro-D-mannitol structure at the reducing end of their chain. The average relative molecular mass is about 5000, 90 percent of which ranges between 2000 and 9000. The degree of sulfation is 2 to 2.5 per disaccharide unit
  • Tinzaparin sodium
  • UNII-12M44VTJ7B
  • UNII-19GW9E1WHN
  • UNII-3S182ET3UA
  • UNII-4UTY6300OM
  • UNII-5XQ9UBJ16W
  • UNII-6DZH9J3B27
  • UNII-N3927D01PB
  • UNII-N816FF9P2W
  • UNII-P59JKU02CE
  • UNII-R5MB4B485P
  • UNII-U6K360XMIU
  • UNII-V5T10N50RD
  • UNII-ZZ45AB24CA
  • Viatromb
  • WY 90493RD
  • Wy-90493 RD
  • Zibor

Systematic Names

  • Depolymerized heparin obtained by peroxide fragmentation of heparin sodium (USP). The end chain structure appears to be the same as the starting material with no unusual sugar residues present. The low molecular weight heparin produced differs from the starting material in molecular weight only. The average relative molecular mass range is 5,500 to 6,500 daltons, with not less
  • Heparin, sodium salt
  • Sodium salt of depolymerized heparin obtained by alkaline degradation of heparin benzyl ester from porcine intestinal mucosa
  • Sodium salt of depolymerized heparin obtained by heparinase from Flavobacterium heparinum (heparin lyase: EC 4.2.2.7) degradation of heparin from pork intestinal mucosa. The majority of the components have a 2-O-sulfo-4-enepyranosuronic acid structure at the non-reducing end and a 2-N:6-O-disulfo-D-glucosamine structure at the reducing end of their chain. The relative molecula
  • Sodium salt of depolymerized heparin obtained by nitrous acid degradation of heparin from pork intestinal mucosa. The majority of the components have a 2-O-sulfo-alpha-L-idopyranosuronic acid structure at the non-reducing end and a 6-O-sulfo-2,5-anhydro-D-mannitol structure at the reducing end of their chain. The average relative molecular mass is about 5000, 90 percent of whi

Registry Numbers

CAS Registry Number

  • 9041-08-1

FDA UNIIs

  • 12M44VTJ7B
  • 19GW9E1WHN
  • 3S182ET3UA
  • 4UTY6300OM
  • 5XQ9UBJ16W
  • 6DZH9J3B27
  • N3927D01PB
  • N816FF9P2W
  • P59JKU02CE
  • R5MB4B485P
  • U6K360XMIU
  • V5T10N50RD
  • ZZ45AB24CA

Other Registry Numbers

  • 101921-26-0
  • 102785-31-9
  • 12656-11-0
  • 913079-23-9

System Generated Number

  • 0009041081

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 1gm/kg (1000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 102, Pg. 156, 1951.
man TDLo subcutaneous 7mg/kg/4D (7mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

BLOOD: HEMORRHAGE

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
JAMA, Journal of the American Medical Association. Vol. 244, Pg. 1831, 1980.
man TDLo subcutaneous 943mg/kg/47W- (943mg/kg) MUSCULOSKELETAL: OSTEOPOROIS Clinical Pharmacology and Therapeutics Vol. 6, Pg. 788, 1965.
mouse LD50 intraperitoneal > 2500mg/kg (2500mg/kg)   Drugs in Japan Vol. -, Pg. 1084, 1990.
mouse LD50 intravenous 2800mg/kg (2800mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 102, Pg. 156, 1951.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 1084, 1990.
mouse LD50 subcutaneous > 2500mg/kg (2500mg/kg)   Drugs in Japan Vol. -, Pg. 1084, 1990.
mouse LD50 unreported 2800mg/kg (2800mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 82, Pg. 280, 1953.
rat LD50 intravenous 391821iu/kg (391821iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
rat LD50 oral > 779000iu/kg (779000iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
rat LD50 subcutaneous 46715iu/kg (46715iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
women TDLo intravenous 700units/kg/1 (700units/kg) BLOOD: THROMBOCYTOPENIA New England Journal of Medicine. Vol. 303, Pg. 788, 1980.
women TDLo subcutaneous 1400units/kg/ (1400units/kg)   Archives of Internal Medicine. Vol. 145, Pg. 1070, 1985.
women TDLo subcutaneous 3400units/kg/ (3400units/kg) SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 313, 1984.