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Substance Name: Ancrod [USAN:INN:BAN]
RN: 9046-56-4
UNII: EL55307L15

Note

  • An enzyme fraction from the venom of the Malayan pit viper, Agkistrodon rhodostoma. It catalyzes the hydrolysis of a number of amino acid esters and a limited proteolysis of fibrinogen. It is used clinically to produce controlled defibrination in patients requiring anticoagulant therapy. EC 3.4.21.-.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Anticoagulant
  • Anticoagulants
  • Cardiovascular Agents
  • Fibrin Modulating Agents
  • Fibrinolytic Agents
  • Hematologic Agents
  • Reproductive Effect
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Links to Resources

Names and Synonyms

Name of Substance

  • Ancrod [USAN:INN:BAN]

MeSH Heading

  • Ancrod

Synonyms

  • A 38414 (Enzyme)
  • Abbott 38414
  • Agkistrododon rhodostoma venom proteinase
  • Ancrod
  • Ancrodo
  • Ancrodo [INN-Spanish]
  • Ancrodum
  • Ancrodum [INN-Latin]
  • Arvin
  • Arwin
  • Brevinase
  • E.C. 3.4.21.28
  • EINECS 232-933-6
  • IRC-50 arvin
  • Proteinase obtained from the venom of the Malayan pit-viper Agkistrodon rhodostoma, acting specifically on fibrinogen
  • UNII-EL55307L15
  • Venacil
  • Viprinex

Systematic Names

  • Proteinase obtained from the venom of the Malayan pit-viper Agkistrodon rhodostoma, acting specifically on fibrinogen
  • Proteinase, agkistrodon rhodostoma venom
  • Proteinase, Agkistrodon serine

Registry Numbers

CAS Registry Number

  • 9046-56-4

FDA UNII

  • EL55307L15

Other Registry Numbers

  • 11126-66-2
  • 37259-86-2
  • 9059-39-6

System Generated Number

  • 0009046564

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 50units/kg (50units/kg) BLOOD: CHANGE IN CLOTTING FACTORS Lancet. Vol. 1, Pg. 486, 1968.
rabbit LDLo intravenous 2.5units/kg (2.5units/kg) BLOOD: CHANGE IN CLOTTING FACTORS Lancet. Vol. 1, Pg. 486, 1968.
rat LDLo intravenous 120units/kg (120units/kg) BLOOD: CHANGE IN CLOTTING FACTORS Lancet. Vol. 1, Pg. 486, 1968.