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Substance Name: Sizofiran [INN:JAN]
RN: 9050-67-3
UNII: 7F763NNC9X

Note

  • A beta-D-glucan obtained from the Aphyllophoral fungus Schizophyllum commune. It is used as an immunoadjuvant in the treatment of neoplasms, especially tumors found in the stomach.

Molecular Formula

  • (C24-H40-O20)mult-

Molecular Weight

  • 666.575
 

Classification Codes

  • Adjuvants, Immunologic
  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Drug / Therapeutic Agent
  • Immunologic Factors
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Links to Resources

Names and Synonyms

Name of Substance

  • Sizofiran
  • Sizofiran [INN:JAN]

MeSH Heading

  • Sizofiran

Synonyms

  • Poly(3-(O-beta-D-glucopyranosyl-(1-3)-O-(beta-D-glucopyranosyl-(1-6))-O-beta-D-glucopyranosyl-(1-3)-O-beta-D-glucopyranosyl)-1)
  • Schizophyllan
  • Schizophyllane
  • Sizofiran
  • Sizofiranum
  • Sizofiranum [Latin]
  • Somfilan
  • SPG
  • UNII-7F763NNC9X

Systematic Names

  • Poly(3->(O-beta-D-glucopyranosyl-(1->3)-O-(beta-D-glucopyranosyl-(1->6))-O-beta-D-glucopyranosyl-(1->3)-O-beta-D-glucopyranosyl)->1)
  • Sizofiran

Registry Numbers

CAS Registry Number

  • 9050-67-3

FDA UNII

  • 7F763NNC9X

System Generated Number

  • 0009050673

Molecular Formulas

Molecular Formula

  • (C24-H40-O20)mult-

Molecular Formula Fragments

  • C24-H40-O20
  • COMPONENT

Structure Descriptors

Smiles

O([C@@H]1[C@H]([C@@H](O[C@@H]([C@H]1O)CO[C@@H]1O[C@@H]([C@@H](O)[C@@H]([C@H]1O)O)CO)O[C@H]1[C@@H]([C@H](O[C@H]([C@@H]1O)O)CO)O)O)[C@@H]1O[C@@H]([C@@H](O)[C@@H]([C@H]1O)O)CO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous > 100mg/kg (100mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 895, 1982.
mouse LD50 intramuscular > 100mg/kg (100mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 895, 1982.
mouse LD50 intraperitoneal > 2gm/kg (2000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 895, 1982.
mouse LD50 intravenous > 300mg/kg (300mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 895, 1982.
mouse LD50 oral > 1gm/kg (1000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 895, 1982.
mouse LD50 subcutaneous > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 895, 1982.
rabbit LD50 intramuscular > 50mg/kg (50mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 895, 1982.
rabbit LD50 intraperitoneal > 200mg/kg (200mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 895, 1982.
rabbit LD50 intravenous > 200mg/kg (200mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 895, 1982.
rabbit LD50 oral > 400mg/kg (400mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 895, 1982.
rabbit LD50 subcutaneous > 100mg/kg (100mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 895, 1982.
rat LD50 intramuscular > 100mg/kg (100mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 895, 1982.
rat LD50 intraperitoneal > 1gm/kg (1000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 895, 1982.
rat LD50 intravenous > 300mg/kg (300mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 895, 1982.
rat LD50 oral > 500mg/kg (500mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 895, 1982.
rat LD50 subcutaneous > 1gm/kg (1000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 895, 1982.