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Substance Name: Tuftsin
RN: 9063-57-4
UNII: QF5336J16C
InChIKey: IESDGNYHXIOKRW-YXMSTPNBSA-N

Note

  • N(2)-((1-(N(2)-L-Threonyl)-L-lysyl)-L-prolyl)-L-arginine. A tetrapeptide produced in the spleen by enzymatic cleavage of a leukophilic gamma-globulin. It stimulates the phagocytic activity of blood polymorphonuclear leukocytes and neutrophils in particular. The peptide is located in the Fd fragment of the gamma-globulin molecule.

Molecular Formula

  • C21-H40-N8-O6

Molecular Weight

  • 500.597
 

Classification Code

  • Immunologic Factors
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Names and Synonyms

Name of Substance

  • Tuftsin

MeSH Heading

  • Tuftsin

Synonym

  • UNII-QF5336J16C

Systematic Name

  • L-Arginine, N2-(1-(N2-L-threonyl-L-lysyl)-L-prolyl)-

Registry Numbers

CAS Registry Number

  • 9063-57-4

FDA UNII

  • QF5336J16C

System Generated Number

  • 0009063574

Structure Descriptors

InChI

1S/C21H40N8O6/c1-12(30)16(23)18(32)27-13(6-2-3-9-22)19(33)29-11-5-8-15(29)17(31)28-14(20(34)35)7-4-10-26-21(24)25/h12-16,30H,2-11,22-23H2,1H3,(H,27,32)(H,28,31)(H,34,35)(H4,24,25,26)/t12-,13+,14+,15+,16+/m1/s1

InChIKey

IESDGNYHXIOKRW-YXMSTPNBSA-N

Smiles

C[C@@H](O)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O