Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Hyaluronate Sodium [USAN:JAN]
RN: 9067-32-7
UNII: YSE9PPT4TH
InChIKey: YWIVKILSMZOHHF-QJZPQSOGSA-N

Note

  • A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the umbilical cord, in vitreous humor, in synovial fluid, in pathologic joints, in group A and C hemolytic streptococci, and in Wharton's jelly. A high urinary level is found in PROGERIA.

Molecular Formula

  • Unspecified

Molecular Weight

  • 799.6366
 

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product
  • Reproductive Effect
  • Synovitis Agent (Veterinary)
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Hyaluronate sodium
  • Hyaluronate Sodium [USAN:JAN]
  • Sodium hyaluronate

Synonyms

  • Arthrease
  • Bio Hyaluro 12
  • CCRIS 4127
  • Chlamyhyaluronic acid sodium salt
  • Cystistat
  • Equron
  • Equron (Veterinary)
  • EUFLEXXA
  • EUFLEXXA injection
  • Healon
  • Hyalart
  • Hyalein
  • Hyalgan
  • Hyalovet
  • Hyaluronate sodium
  • Hyalurone sodium
  • Hyaluronic acid sodium
  • Hyaluronsan HA-LQ
  • Hyasol
  • Hyladerm
  • Hyladerm Khionat
  • Khionat
  • Legend
  • Monovisc
  • Nidelon
  • NRD101
  • Orthovisc
  • Ostenil
  • Provisc
  • SI-4402
  • Sinovial
  • SL 1010
  • SL-1010
  • Sodium hyaluronate
  • Sodium hyaluronate HMW
  • SPH
  • Supartz
  • Suvenyl
  • Synacid
  • Synacid (veterinary)
  • UNII-YSE9PPT4TH

Systematic Names

  • Hyaluronic acid, sodium salt
  • Sodium hyaluronate

Registry Numbers

CAS Registry Number

  • 9067-32-7

FDA UNII

  • YSE9PPT4TH

Other Registry Numbers

  • 1319723-90-4
  • 1430231-35-8
  • 34448-35-6

Related Registry Number

  • 9004-61-9 (Parent)

System Generated Number

  • 0009067327

Structure Descriptors

InChI

1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1

InChIKey

YWIVKILSMZOHHF-QJZPQSOGSA-N

Smiles

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C(=O)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(=O)O)O)O)O)NC(=O)C)O)O.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 subcutaneous > 50mg/kg (50mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl,
mouse LD50 intraperitoneal 1500mg/kg (1500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 1013, 1984.
mouse LD50 oral > 2400mg/kg (2400mg/kg)   Drugs in Japan Vol. -, Pg. 849, 1990.
mouse LD50 subcutaneous > 4gm/kg (4000mg/kg) BEHAVIORAL: ATAXIA Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rabbit LD50 intraperitoneal 1820mg/kg (1820mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BLOOD: NORMOCYTIC ANEMIA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rabbit LD50 oral > 1gm/kg (1000mg/kg)   Drugs in Japan Vol. -, Pg. 849, 1990.
rabbit LD50 subcutaneous > 2gm/kg (2000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rabbit LD50 subcutaneous > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rat LD50 intraperitoneal 1770mg/kg (1770mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BLOOD: NORMOCYTIC ANEMIA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rat LD50 oral > 800mg/kg (800mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rat LD50 subcutaneous > 4gm/kg (4000mg/kg) BEHAVIORAL: ATAXIA Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.