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Substance Name: Necitumumab [USAN:INN]
RN: 906805-06-9
UNII: 2BT4C47RUI

Notes

  • A fully human antibody that has similar antitumor potency as the chimeric cetuximab/Erbitux and might represent a safer therapeutic alternative in EGF receptor inhibition.
  • A fully human antibody that has similar antitumor potency as the chimeric cetuximab/Erbitux and might represent a safer therapeutic alternative in EGF receptor inhibition.

    NCI: A fully human IgG1 monoclonal antibody directed against the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. Necitumumab binds to and blocks the ligand binding site of EGFR, thereby preventing the activation and subsequent dimerization of the receptor. This may lead to an inhibition of EGFR-dependent downstream pathways and so inhibition of EGFR-dependent tumor cell proliferation and metastasis. EGFR, a member of the epidermal growth factor family of extracellular protein ligands, may be overexpressed on the cell surfaces of various tumor cell types. (NCI Thesaurus)

Molecular Formulas

  • C6436-H9958-N1702-O2020-S42
  • Unspecified
 

Classification Codes

  • Antineoplastic Agents
  • Treatment of Cancer
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Links to Resources

NLM Resources (File Locators)

Other Resources (Internet Locators)

Names and Synonyms

Name of Substance

  • Necitumumab
  • Necitumumab [USAN:INN]

Synonyms

  • IMC 11F8
  • IMC-11F8
  • Immunoglobulin G1, anti-(human epidermal growth factor receptor (receptor tyrosine-protein kinase ErbB-1, EC 2.7.10.1)); human monoclonal IMC-11F8 gamma1 heavy chain (224-214')-disulfide with human monoclonal IMC-11F8 kappa light chain, dimer (230- 230'':233-233'')-bisdisulfide
  • Necitumumab
  • Portrazza
  • UNII-2BT4C47RUI

Systematic Name

  • Immunoglobulin G1, anti-(human epidermal growth factor receptor) (human monoclonal IMC-11F8 gamma1-chain), disulfide with human monoclonal IMC-11F8 kappa-chain, dimer

Registry Numbers

CAS Registry Number

  • 906805-06-9

FDA UNII

  • 2BT4C47RUI

System Generated Number

  • 0906805069