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Substance Name: Ebastine [USAN:INN:BAN]
RN: 90729-43-4
UNII: TQD7Q784P1
InChIKey: MJJALKDDGIKVBE-UHFFFAOYSA-N

Note

  • A second generation antihistamine.

Molecular Formula

  • C32-H39-N-O2

Molecular Weight

  • 469.665
 

Classification Codes

  • Antihistaminic
  • Drug / Therapeutic Agent
  • Histamine Agents
  • Histamine Antagonists
  • Histamine H1 Antagonists
  • Neurotransmitter Agents
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Ebastine
  • Ebastine [USAN:INN:BAN]

Synonyms

  • 1-(4-(1,1-Dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidinyl)-1-butanone
  • 1-Butanone, 1-(4-(1,1-dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidinyl)-
  • 4'-tert-Butyl-4-(4-(diphenylmethoxy)piperidino)butyrophenone
  • 4-Diphenylmethoxy-1-(3-(4-tert-butylbenzoyl)propyl)piperidine
  • Ebastel
  • Ebastina
  • Ebastina [Spanish]
  • Ebastine
  • Ebastinum
  • Ebastinum [Latin]
  • Kestine
  • LAS W-090
  • RP 64305
  • UNII-TQD7Q784P1

Systematic Name

  • 1-Butanone, 1-(4-(1,1-dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidinyl)-

Registry Numbers

CAS Registry Number

  • 90729-43-4

FDA UNII

  • TQD7Q784P1

System Generated Number

  • 0090729434

Structure Descriptors

InChI

1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3

InChIKey

MJJALKDDGIKVBE-UHFFFAOYSA-N

Smiles

C(c1ccccc1)(c1ccccc1)OC1CCN(CCCC(c2ccc(C(C)(C)C)cc2)=O)CC1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 160mg/kg (160mg/kg)   Medicamentos de Actualidad. Vol. 28(Suppl,
mammal (species unspecified) LD50 intraperitoneal 500mg/kg (500mg/kg)   Drugs of the Future. Vol. 15, Pg. 674, 1990.
mammal (species unspecified) LD50 oral > 4gm/kg (4000mg/kg)   Drugs of the Future. Vol. 15, Pg. 674, 1990.
mouse LD50 intraperitoneal 446mg/kg (446mg/kg)   Medicamentos de Actualidad. Vol. 28(Suppl,
mouse LD50 oral > 4gm/kg (4000mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE Medicamentos de Actualidad. Vol. 28(Suppl,
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 1143, 1994.
rat LD50 intraperitoneal 496mg/kg (496mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 1143, 1994.
rat LD50 intraperitoneal 496mg/kg (496mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 1143, 1994.
rat LD50 oral > 4gm/kg (4000mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE Medicamentos de Actualidad. Vol. 28(Suppl,
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 1143, 1994.