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Substance Name: Metyrapone tartrate [USAN]
RN: 908-35-0
UNII: B6DRB5ZI7P
InChIKey: FBSAWAHQGRDEJD-WBPXWQEISA-N

Note

  • An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.

Molecular Formula

  • C14-H14-N2-O.2C4-H6-O6

Molecular Weight

  • 526.4484
 

Classification Codes

  • Antimetabolites
  • Diagnostic Aid (Pituitary Function Determination)
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Metyrapone tartrate [USAN]

Synonyms

  • 1-Propanone, 2-methyl-1,2-di-3-pyridinyl-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:2)
  • 1-Propanone, 2-methyl-1,2-di-3-pyridyl-, ditartrate (6IC)
  • 2-Methyl-1,2-di-3-pyridyl-1-propanone tartrate (1:2)
  • 2-Methyl-1,2-dipyridyl-3'-1-oxopropane ditartrate
  • Metopirone ditartrate
  • Metopirone tartrate
  • Metyprapone bitartrate
  • Metyrapone ditartrate
  • Metyrapone tartrate
  • SU 4885
  • Su-4885
  • UNII-B6DRB5ZI7P

Systematic Names

  • 1-Propanone, 2-methyl-1,2-di-3-pyridinyl-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:2)
  • 1-Propanone, 2-methyl-1,2-di-3-pyridyl-, tartrate (1:2)

Registry Numbers

CAS Registry Number

  • 908-35-0

FDA UNII

  • B6DRB5ZI7P

System Generated Number

  • 0000908350

Molecular Formulas

Molecular Formula

  • C14-H14-N2-O.2C4-H6-O6

Molecular Formula Fragments

  • C14-H14-N2-O
  • C4-H6-O6
  • COMPONENT

Structure Descriptors

InChI

1S/C14H14N2O.2C4H6O6/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11;2*5-1(3(7)8)2(6)4(9)10/h3-10H,1-2H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t;2*1-,2-/m.11/s1

InChIKey

FBSAWAHQGRDEJD-WBPXWQEISA-N

Smiles

CC(C)(C(=O)c1cccnc1)c2cccnc2.O[C@H]([C@@H](O)C(=O)O)C(=O)O.O[C@H]([C@@H](O)C(=O)O)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 760mg/kg (760mg/kg) BEHAVIORAL: ANTIPSYCHOTIC Toxicology. Vol. 17, Pg. 73, 1980.
mouse LD50 intravenous 261mg/kg (261mg/kg)   Toxicology and Applied Pharmacology. Vol. 23, Pg. 537, 1972.