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Substance Name: Rhizoxin
RN: 90996-54-6
UNII: C1V1Y784E4
InChIKey: OWPCHSCAPHNHAV-QIPOKPRISA-N

Note

  • From Rhizopus chinensis; causal agent of rice seedling blight.

Molecular Formula

  • C35-H47-N-O9

Molecular Weight

  • 625.754
 

Classification Codes

  • Anti-Infective Agents
  • Antibiotics, Antineoplastic
  • Antifungal Agents
  • Antimitotic Agents
  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Mitosis Modulators
  • Mutation Data
  • Natural Product
  • Tubulin Modulators
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Names and Synonyms

Name of Substance

  • Rhizoxin

Synonyms

  • Antibiotic WF-1360
  • BRN 5692896
  • NSC 332598
  • Rhizoxin
  • UNII-C1V1Y784E4
  • WF-1360

Systematic Name

  • Rhizoxin

Registry Numbers

CAS Registry Number

  • 90996-54-6

FDA UNII

  • C1V1Y784E4

System Generated Number

  • 0090996546

Structure Descriptors

InChI

1S/C35H47NO9/c1-19(13-25-18-41-23(5)36-25)9-8-10-21(3)32(40-7)22(4)27-17-29(37)35(6)30(45-35)12-11-20(2)26-14-24(16-31(38)42-26)15-28-33(43-28)34(39)44-27/h8-13,18,20,22,24,26-30,32-33,37H,14-17H2,1-7H3/b9-8+,12-11+,19-13+,21-10+/t20-,22+,24+,26-,27+,28+,29+,30-,32+,33-,35-/m1/s1

InChIKey

OWPCHSCAPHNHAV-QIPOKPRISA-N

Smiles

O1[C@H]2[C@]1([C@H](C[C@@H]([C@H](C)[C@H](\C(=C\C=C\C(=C\c1nc(C)oc1)C)C)OC)OC([C@@H]1O[C@H]1C[C@@H]1C[C@H]([C@@H](C=C2)C)OC(C1)=O)=O)O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 2500ug/kg (2.5mg/kg)   Journal of Antibiotics. Vol. 39, Pg. 762, 1986.
mouse LD50 intravenous 3700ug/kg (3.7mg/kg) BEHAVIORAL: ATAXIA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Annals of Oncology. Vol. 3, Pg. 755, 1992.