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Substance Name: Tribulin
RN: 91-56-5
UNII: 82X95S7M06
InChIKey: JXDYKVIHCLTXOP-UHFFFAOYSA-N

Notes

  • An indole-dione that is obtained by oxidation of indigo blue. It is a MONOAMINE OXIDASE INHIBITOR and high levels have been found in urine of PARKINSONISM patients.
  • Endogenous MONOAMINE OXIDASE inhibitory activity extractable into ethyl acetate found in brain and many mammalian tissues and fluids; ISATIN is a major component; produced in excess following alcohol withdrawal.

Molecular Formula

  • C8-H5-N-O2

Molecular Weight

  • 147.1325
 

Classification Codes

  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Monoamine Oxidase Inhibitors
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Tribulin

MeSH Heading

  • Isatin

Synonyms

  • 2,3-Diketoindoline
  • 2,3-Dioxo-2,3-dihydroindole
  • 2,3-Dioxoindoline
  • 2,3-Indolinedione
  • 2,3-Ketoindoline
  • 5-21-10-00221 (Beilstein Handbook Reference)
  • AI3-03111
  • BRN 0383659
  • EC 202-077-8
  • EINECS 202-077-8
  • Isatic acid lactam
  • Isatin
  • Isatine
  • Isatinic acid anhydride
  • Isotin
  • NSC 9262
  • o-Aminobenzoylformic anhydride
  • Pseudoisatin
  • UNII-82X95S7M06

Systematic Names

  • 1H-Indole-2,3-dione
  • Indole-2,3-dione
  • Indoline-2,3-dione

Registry Numbers

CAS Registry Number

  • 91-56-5

FDA UNII

  • 82X95S7M06

Other Registry Numbers

  • 5815-00-9
  • 84788-92-1

System Generated Number

  • 0000091565

Structure Descriptors

InChI

1S/C8H5NO2/c10-7-5-3-1-2-4-6(5)9-8(7)11/h1-4H,(H,9,10,11)

InChIKey

JXDYKVIHCLTXOP-UHFFFAOYSA-N

Smiles

c1ccc2c(c1)C(=O)C(=O)N2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 330mg/kg (330mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 55, Pg. 1514, 1959.
rat LD intravenous > 800mg/kg (800mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Indian Journal of Physiology and Pharmacology. Vol. 6, Pg. 145, 1962.
rat LD50 intraperitoneal 7740mg/kg (7740mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 27(8), Pg. 54, 1983.
rat LD50 unreported 725mg/kg (725mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Russian Pharmacology and Toxicology Vol. 41, Pg. 146, 1978.
rat LDLo oral 5gm/kg (5000mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Indian Journal of Physiology and Pharmacology. Vol. 6, Pg. 145, 1962.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 203 dec deg C   EXP
log P (octanol-water) 0.83 (none)   EXP
Water Solubility 1.53E+04 mg/L 25 EST
Vapor Pressure 1.11E-05 mm Hg 25 EST
Henry's Law Constant 2.21E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.89E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.