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Substance Name: Tribulin
RN: 91-56-5
UNII: 82X95S7M06
InChIKey: JXDYKVIHCLTXOP-UHFFFAOYSA-N
Notes
- An indole-dione that is obtained by oxidation of indigo blue. It is a MONOAMINE OXIDASE INHIBITOR and high levels have been found in urine of PARKINSONISM patients.
- Endogenous MONOAMINE OXIDASE inhibitory activity extractable into ethyl acetate found in brain and many mammalian tissues and fluids; ISATIN is a major component; produced in excess following alcohol withdrawal.
Molecular Formula
- C8-H5-N-O2
Molecular Weight
- 147.1325
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Monoamine Oxidase Inhibitors
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Tribulin
MeSH Heading
- Isatin
Synonyms
- 2,3-Diketoindoline
- 2,3-Dioxo-2,3-dihydroindole
- 2,3-Dioxoindoline
- 2,3-Indolinedione
- 2,3-Ketoindoline
- 5-21-10-00221 (Beilstein Handbook Reference)
- AI3-03111
- BRN 0383659
- EC 202-077-8
- EINECS 202-077-8
- Isatic acid lactam
- Isatin
- Isatine
- Isatinic acid anhydride
- Isotin
- NSC 9262
- o-Aminobenzoylformic anhydride
- Pseudoisatin
- UNII-82X95S7M06
Systematic Names
- 1H-Indole-2,3-dione
- Indole-2,3-dione
- Indoline-2,3-dione
Registry Numbers
CAS Registry Number
- 91-56-5
FDA UNII
- 82X95S7M06
Other Registry Numbers
- 5815-00-9
- 84788-92-1
System Generated Number
- 0000091565
Structure Descriptors
InChI
InChI=1S/C8H5NO2/c10-7-5-3-1-2-4-6(5)9-8(7)11/h1-4H,(H,9,10,11)InChIKey
JXDYKVIHCLTXOP-UHFFFAOYSA-NSmiles
O=C1Nc2ccccc2C1=OToxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 330mg/kg (330mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 55, Pg. 1514, 1959. | |
| rat | LD | intravenous | > 800mg/kg (800mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Indian Journal of Physiology and Pharmacology. Vol. 6, Pg. 145, 1962. |
| rat | LD50 | intraperitoneal | 7740mg/kg (7740mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 27(8), Pg. 54, 1983. | |
| rat | LD50 | unreported | 725mg/kg (725mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Russian Pharmacology and Toxicology Vol. 41, Pg. 146, 1978. |
| rat | LDLo | oral | 5gm/kg (5000mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Indian Journal of Physiology and Pharmacology. Vol. 6, Pg. 145, 1962. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 203 dec | deg C | EXP | |
| log P (octanol-water) | 0.83 | (none) | EXP | |
| Water Solubility | 1.53E+04 | mg/L | 25 | EST |
| Vapor Pressure | 1.11E-05 | mm Hg | 25 | EST |
| Henry's Law Constant | 2.21E-11 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 3.89E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.