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Substance Name: Antazoline [INN:BAN]
RN: 91-75-8
UNII: DHA8014SS1
InChIKey: REYFJDPCWQRWAA-UHFFFAOYSA-N

Note

  • An antagonist of histamine H1 receptors.

Molecular Formula

  • C17-H19-N3

Molecular Weight

  • 265.3581
 

Classification Codes

  • Anti-Allergic Agents
  • Drug / Therapeutic Agent
  • Histamine Agents
  • Histamine Antagonists
  • Histamine H1 Antagonists
  • Neurotransmitter Agents
  • Skin / Eye Irritant
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Names and Synonyms

Name of Substance

  • Antazoline
  • Antazoline [INN:BAN]

MeSH Heading

  • Antazoline

Synonyms

  • 2-(N-Benzylanilinomethyl)-2-imidazoline
  • 2-(N-Phenyl-N-benzylaminomethyl)imidazoline
  • 2-Phenyl-benzyl-amino-methylimidazolin
  • 2-Phenyl-benzyl-amino-methylimidazolin [German]
  • 4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine
  • 5-25-09-00364 (Beilstein Handbook Reference)
  • 5512-M
  • Antastan
  • Antasten
  • Antazolin
  • Antazolina
  • Antazolina [INN-Spanish]
  • Antazolina [Spanish]
  • Antazoline
  • Antazolinum
  • Antazolinum [INN-Latin]
  • Antazolinum [Latin]
  • Antihistal
  • Antistin
  • Antistine
  • Azalone
  • Ben-A-hist
  • BRN 0233924
  • EINECS 202-094-0
  • Histostab
  • HSDB 6506
  • Imidamin
  • Imidamine
  • Phenazolin
  • Phenazoline
  • UNII-DHA8014SS1

Systematic Names

  • 1H-Imidazole-2-methanamine, 4,5-dihydro-N-phenyl-N-(phenylmethyl)-
  • 2-Imidazoline, 2-((N-benzylanilino)methyl)-
  • Antazoline

Registry Numbers

CAS Registry Number

  • 91-75-8

FDA UNII

  • DHA8014SS1

Related Registry Numbers

  • 154-68-7 (phosphate (1:1))
  • 2508-72-7 (hydrochloride)

System Generated Number

  • 0000091758

Structure Descriptors

InChI

1S/C17H19N3/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,18,19)

InChIKey

REYFJDPCWQRWAA-UHFFFAOYSA-N

Smiles

c1ccc(cc1)CN(CC2=NCCN2)c3ccccc3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 100mg/kg (100mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 237, Pg. 171, 1959.
mouse LD50 intravenous 61mg/kg (61mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 188, Pg. 189, 1970.
mouse LD50 oral 398mg/kg (398mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 237, 1957.
mouse LD50 subcutaneous 135mg/kg (135mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 214, 1967.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 120 deg C   EXP
log P (octanol-water) 3.380 (none)   EST
Water Solubility 663 mg/L 30 EXP
Atmospheric OH Rate Constant 2.41E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.