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Substance Name: Tripelennamine [INN:BAN]
RN: 91-81-6
UNII: 3C5ORO99TY
InChIKey: UFLGIAIHIAPJJC-UHFFFAOYSA-N

Note

  • A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat ASTHMA; HAY FEVER; URTICARIA; and RHINITIS; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.

Molecular Formula

  • C16-H21-N3

Molecular Weight

  • 255.363
 

Classification Codes

  • Anti-Allergic Agents
  • Drug / Therapeutic Agent
  • Histamine Agents
  • Histamine Antagonists
  • Histamine H1 Antagonists
  • Mutation Data
  • Neurotransmitter Agents

Names and Synonyms

Name of Substance

  • Tripelennamine
  • Tripelennamine [INN:BAN]

MeSH Heading

  • Tripelennamine

Synonyms

  • 1,2-Ethanediamine, N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-
  • 2-(Benzyl(2-dimethylaminoethyl)amino)pyridine
  • 2-(N-Benzyl-N-(2-dimethylaminoethyl)amino)pyridine
  • 2750 R.P.
  • 5-22-08-00378 (Beilstein Handbook Reference)
  • Benzoxale
  • Benzyl-(alpha-pyridyl)-dimethylaethylendiamin
  • Benzyl-(alpha-pyridyl)-dimethylaethylendiamin [German]
  • beta-Dimethylaminoethyl-2-pyridylaminotoluene
  • beta-Dimethylaminoethyl-2-pyridylbenzylamine
  • BRN 0227074
  • Cizaron
  • EINECS 202-100-1
  • Ethylenediamine, N-benzyl-N',N'-dimethyl-N-(2-pyridyl)-
  • HSDB 5191
  • N,N-Dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-1,2-ethanediamine
  • N,N-Dimethyl-N'-benzyl-N'-(2-pyridyl)ethylenediamine
  • N,N-Dimethyl-N'-benzyl-N'-(alpha-pyridyl)ethylenediamine
  • N-Benzyl-N',N'-dimethyl-N-2-pyridylethylenediamine
  • N-Benzyl-N-(2-pyridyl)-N',N'-dimethyl ethylenediamine
  • NCI-C60662
  • NSC 118946
  • PBZ
  • Piribenzil
  • Pyribenzamine
  • Pyridine, 2-(benzyl(2-(dimethylamino)ethyl)amino)-
  • Pyrinamine base
  • Resistamine
  • Tonaril
  • Tripelenamina
  • Tripelenamina [INN-Spanish]
  • Tripelennamin
  • Tripelennamina
  • Tripelennamina [Italian]
  • Tripelennamine
  • Tripelennaminum
  • Tripelennaminum [INN-Latin]
  • Ts and Blues
  • UNII-3C5ORO99TY
  • Vetibenzamina

Systematic Names

  • 1,2-Ethanediamine, N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-
  • 1,2-Ethanediamine, N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl- (9CI)
  • Pyridine, 2-(benzyl(2-(dimethylamino)ethyl)amino)-
  • Tripelennamine

Registry Numbers

CAS Registry Number

  • 91-81-6

FDA UNII

  • 3C5ORO99TY

Related Registry Numbers

  • 154-69-8 (mono-hydrochloride)
  • 22306-05-4 (hydrochloride)
  • 58044-99-8 (maleate (1:1))
  • 6138-56-3 (citrate (1:1))

System Generated Number

  • 0000091816

Structure Descriptors

InChI

1S/C16H21N3/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15/h3-11H,12-14H2,1-2H3

InChIKey

UFLGIAIHIAPJJC-UHFFFAOYSA-N

Smiles

N(c1ccccn1)(Cc1ccccc1)CCN(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 64mg/kg (64mg/kg)   Therapie. Vol. 28, Pg. 767, 1973.
mammal (species unspecified) LD50 subcutaneous 61mg/kg (61mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 131, 1957.
mouse LD50 intraperitoneal 43mg/kg (43mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 237, 1957.
mouse LD50 intravenous 23mg/kg (23mg/kg)   Japanese Journal of Toxicology. Vol. 4, Pg. 105, 1991.
mouse LD50 oral 152mg/kg (152mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 237, 1957.
rat LDLo intraperitoneal 37mg/kg (37mg/kg)   Toxicology and Applied Pharmacology. Vol. 1, Pg. 156, 1959.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 2.730 (none)   EST
Water Solubility 587 mg/L 30 EXP
Atmospheric OH Rate Constant 1.31E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.