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Substance Name: Thonzylamine [INN:BAN]
RN: 91-85-0
UNII: R79646H5Z8
InChIKey: GULNIHOSWFYMRN-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Histamine Agents
  • Histamine Antagonists
  • Human Data
  • Neurotransmitter Agents
  • Reproductive Effect

Molecular Formula

  • C16-H22-N4-O

Molecular Weight

  • 286.377
 
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Names and Synonyms

Results Name

  • Thonzylamine [INN:BAN]

Name of Substance

  • Thonzylamine
  • Thonzylamine [INN:BAN]

Synonyms

  • 2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)pyrimidine
  • 4-25-00-02087 (Beilstein Handbook Reference)
  • BRN 0284655
  • EINECS 202-103-8
  • Ethylenediamine, N-(p-methoxybenzyl)-N',N'-dimethyl-N-2-pyrimidinyl-
  • N,N-Dimethyl-N'-(p-methoxybenzyl)-N'-(2-pyrimidyl)ethylenediamine
  • NCI-C60708
  • Neohetramine
  • Thonzylamine
  • Thonzylaminum
  • Thonzylaminum [INN-Latin]
  • Toncilaminio
  • Toncilaminio [INN-Spanish]
  • Tonzilamina
  • Tonzilamina [DCIT]
  • Tonzilamine
  • UNII-R79646H5Z8

Systematic Names

  • 1,2-Ethanediamine, N-((4-methoxyphenyl)methyl)-N',N'-dimethyl-N-2-pyrimidinyl-
  • Pyrimidine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-
  • Thonzylamine

Registry Numbers

CAS Registry Number

  • 91-85-0

FDA UNII

  • R79646H5Z8

Related Registry Number

  • 63-56-9 (mono-hydrochloride)

System Generated Number

  • 0000091850

Structure Descriptors

InChI

1S/C16H22N4O/c1-19(2)11-12-20(16-17-9-4-10-18-16)13-14-5-7-15(21-3)8-6-14/h4-10H,11-13H2,1-3H3

InChIKey

GULNIHOSWFYMRN-UHFFFAOYSA-N

Smiles

N(c1ncccn1)(Cc1ccc(OC)cc1)CCN(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 493mg/kg (493mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 66, Pg. 512, 1947.
mouse LD50 intraperitoneal 119mg/kg (119mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 66, Pg. 512, 1947.
mouse LD50 oral 245mg/kg (245mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 66, Pg. 512, 1947.
women TDLo oral 2mg/kg (2mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: GENERAL ANESTHETIC

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Journal of Allergy. Vol. 19, Pg. 313, 1948.