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Substance Name: Rabusertib [USAN:INN]
RN: 911222-45-2
UNII: 3S9L1NU6U7
InChIKey: SYYBDNPGDKKJDU-ZDUSSCGKSA-N

Notes

  • A checkpoint 1 kinase inhibitor.
  • A checkpoint 1 kinase inhibitor

    An inhibitor of the cell cycle checkpoint kinase 2 (chk2) with potential chemopotentiating activity. Rabusertib binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk2, an ATP-dependent serine-threonine kinase, is a key component in the DNA replication-monitoring checkpoint system and is activated by double-stranded breaks (DSBs); activated chk2 is overexpressed by a variety of cancer cell types. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

Molecular Weight

  • 436.3078
 
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Names and Synonyms

Name of Substance

  • Rabusertib [USAN:INN]

Synonyms

  • Ly 2603618
  • Ly2603618
  • Rabusertib
  • UNII-3S9L1NU6U7
  • Urea, N-(5-bromo-4-methyl-2-((2S)-2-morpholinylmethoxy)phenyl)-N'-(5-methyl-2- pyrazinyl)-

Registry Numbers

CAS Registry Number

  • 911222-45-2

FDA UNII

  • 3S9L1NU6U7

System Generated Number

  • 0911222452

Structure Descriptors

InChI

1S/C18H22BrN5O3/c1-11-5-16(27-10-13-8-20-3-4-26-13)15(6-14(11)19)23-18(25)24-17-9-21-12(2)7-22-17/h5-7,9,13,20H,3-4,8,10H2,1-2H3,(H2,22,23,24,25)/t13-/m0/s1

InChIKey

SYYBDNPGDKKJDU-ZDUSSCGKSA-N

Smiles

Cc1cc(c(cc1Br)NC(=O)Nc2cnc(cn2)C)OC[C@@H]3CNCCO3