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Substance Name: Veliparib [USAN:INN]
RN: 912444-00-9
UNII: 01O4K0631N
InChIKey: JNAHVYVRKWKWKQ-CYBMUJFWSA-N

Notes

  • An orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models.
  • An orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models.

    NCI: A poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with chemosensitizing and antitumor activities. With no antiproliferative effects as a single agent at therapeutic concentrations, ABT-888 inhibits PARPs, thereby inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents. PARP nuclear enzymes are activated by DNA single or double strand breaks, resulting in the poly(ADP-ribosyl)ation of other nuclear DNA binding proteins involved in DNA repair; poly(ADP-ribosyl)ation contributes to efficient DNA repair and to survival of proliferating cells exposed to mild genotoxic stresses as induced by as oxidants, alkylating agents or ionizing radiation. (NCI Thesaurus)

Molecular Formula

  • C13-H16-N4-O

Molecular Weight

  • 244.2964
 

Classification Codes

  • Antineoplastic Agents
  • Antineoplastic Enhancing Agent
  • Enzyme Inhibitors
  • Poly(ADP-ribose) Polymerase Inhibitors
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Names and Synonyms

Results Name

  • Veliparib [USAN:INN]

Name of Substance

  • Veliparib
  • Veliparib [USAN:INN]

Synonyms

  • A861695
  • ABT 888
  • ABT-888
  • UNII-01O4K0631N
  • Veliparib

Systematic Name

  • 1H-Benzimidazole-4-carboxamide, 2-((2R)-2-methyl-2-pyrrolidinyl)-

Registry Numbers

CAS Registry Number

  • 912444-00-9

FDA UNII

  • 01O4K0631N

System Generated Number

  • 0912444009

Structure Descriptors

InChI

InChI=1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1

InChIKey

JNAHVYVRKWKWKQ-CYBMUJFWSA-N

Smiles

C[C@@]1(CCCN1)c2nc3c(cccc3[nH]2)C(=O)N