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Substance Name: Elsiglutide [INN]
RN: 914009-84-0


  • NCI: A synthetic glucagon-like peptide-2 (GLP-2) analogue with potential antidiarrheal and intestinotrophic activities. Upon subcutaneous administration, elsiglutide, a 39 amino acid polypeptide, binds to GLP-2 receptors and thereby promotes proliferation of epithelial cells. Regeneration of endothelial cells damaged during chemotherapy may prevent or decrease chemotherapy-induced diarrhea. In addition, elsiglutide may prevent chemotherapy-induced intestinal injury. GLP-2, a peptide hormone primarily produced in the small intestines in response to food, plays a key role in intestinal epithelial growth, metabolism and regeneration of epithelial cells. [NCI Drug Dictionary]
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Names and Synonyms

Name of Substance

  • Elsiglutide
  • Elsiglutide [INN]


  • Elsiglutide
  • UNII-SC864Q40VB
  • ZP 1846

Registry Numbers

CAS Registry Number

  • 914009-84-0


  • SC864Q40VB

System Generated Number

  • 0914009840