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Substance Name: Brentuximab vedotin [USAN:INN]
RN: 914088-09-8
UNII: 7XL5ISS668

Notes

  • Consists of cAC10 conjugated to monomethylauristatin E.
  • Consists of cAC10 conjugated to monomethylauristatin E.

    NCI: An antibody-drug conjugate (ADC) directed against the tumor necrosis factor (TNF) receptor CD30 with potential antineoplastic activity. Brentuximab vedotin is generated by conjugating the humanized anti-CD30 monoclonal antibody SGN-30 to the cytotoxic agent monomethyl auristatin E (MMAE) via a valine-citrulline peptide linker ... (NCI Thesaurus)

Molecular Formula

  • Unspecified

Molecular Weight

  • 1349.7134
 

Classification Code

  • Treatment of Hodgkin's Lymphoma, CD30-Positive Hematologic Malignancies

Names and Synonyms

Name of Substance

  • Brentuximab vedotin [USAN:INN]

Synonyms

  • Adcetris
  • Anti-CD30 ADC SGN-35
  • Anti-CD30 antibody-drug conjugate SGN-35
  • Antibody-drug conjugate SGN-35
  • Brentuximab Vedotin
  • cAC10-vcMMAE
  • SGN 35
  • SGN-35
  • UNII-7XL5ISS668

Systematic Name

  • Immunoglobulin G1, anti-(human CD30 (antigen)) (human-mouse monoclonal cAC10 gamma1-chain), disulfide with human-mouse monoclonal cAC10 kappa-chain, dimer, complex with N-(((4-((N-(6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl)-L-valyl-N5-(aminocarbonyl)-L-ornithyl)amino)phenyl)methoxy)carbonyl)-N-methyl-L-valyl-N-((1S,2R)-4-((2S)-2-((1R,2R)-3-(((1R,2S)-2-hydroxy-1-methyl-2-phenylethyl)amino)-1-methoxy-2-methyl-3-oxopropyl)-1-pyrrolidinyl)-2-methoxy-1-((1S)-1-ethylpropyl)-4-oxobutyl)-N-methyl-L-valinamide

Registry Numbers

CAS Registry Number

  • 914088-09-8

FDA UNII

  • 7XL5ISS668

System Generated Number

  • 0914088098