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Substance Name: Fostamatinib disodium [USAN]
RN: 914295-16-2
UNII: 86EEZ49YVB
InChIKey: ZQGJCHHKJNSPMS-UHFFFAOYSA-L

Note

  • A spleen tyrosine kinase (Syk) inhibitor, metabolized to R406.

    NCI: /Fostamatinib disodium/ An orally available disodium salt of the Syk kinase inhibitor fostamatinib with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis

Molecular Formula

  • C23-H24-F-N6-Na2-O9-P.6(H2-O)

Molecular Weight

  • 732.5164
 

Classification Codes

  • Treatment of B-Cell Lymphoma
  • Treatment of Immune Thrombocytopenic Purpura
  • Treatment of Rheumatoid Arthritis
  • Treatment of Rheumatoid Arthritis, Immune Thrombocytopenic Purpura, and B-Cell Lymphoma
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Names and Synonyms

Name of Substance

  • Fostamatinib disodium [USAN]

Synonyms

  • (6-((5-Fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido(3,2-b)-1,4-oxazin-4-yl)methyl disodium phosphate hexahydrate
  • Fostamatinib disodium
  • R 788 sodium
  • R 935788 sodium
  • R788 sodium
  • R935788
  • R935788 sodium
  • Tavalisse
  • UNII-86EEZ49YVB

Systematic Name

  • 2H-Pyrido(3,2-b)-1,4-oxazin-3(4H)-one, 6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)-4-pyrimidinyl)amino)-2,2-dimethyl-4-((phosphonooxy)methyl)-, disodium salt, hexahydrate

Registry Numbers

CAS Registry Number

  • 914295-16-2

FDA UNII

  • 86EEZ49YVB

System Generated Number

  • 0914295162

Structure Descriptors

InChI

1S/C23H26FN6O9P.2Na.6H2O/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4;;;;;;;;/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29);;;6*1H2/q;2*+1;;;;;;/p-2

InChIKey

ZQGJCHHKJNSPMS-UHFFFAOYSA-L

Smiles

O.O.O.O.O.O.[Na+].[Na+].COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)N(COP(=O)([O-])[O-])c4n3)n2)cc(OC)c1OC