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Substance Name: Enzalutamide [USAN:INN]
RN: 915087-33-1
UNII: 93T0T9GKNU
InChIKey: WXCXUHSOUPDCQV-UHFFFAOYSA-N

Note

  • An antineoplastic agent.

    NCI: An orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, enzalutamide inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance. (NCI Thesaurus)

Molecular Formula

  • C21-H16-F4-N4-O2

Molecular Weight

  • 464.4414
 

Names and Synonyms

Name of Substance

  • Enzalutamide [USAN:INN]
  • MDV 3100

Synonyms

  • Enzalutamide
  • MDV 3100
  • MDV-3100
  • MDV3100
  • UNII-93T0T9GKNU
  • Xtandi

Systematic Name

  • Benzamide, 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl)-2-fluoro-N-methyl-

Registry Numbers

CAS Registry Number

  • 915087-33-1

FDA UNII

  • 93T0T9GKNU

System Generated Number

  • 0915087331

Structure Descriptors

InChI

InChI=1S/C21H16F4N4O2S/c1-20(2)18(31)28(12-5-4-11(10-26)15(8-12)21(23,24)25)19(32)29(20)13-6-7-14(16(22)9-13)17(30)27-3/h4-9H,1-3H3,(H,27,30)

InChIKey

WXCXUHSOUPDCQV-UHFFFAOYSA-N

Smiles

CNC(=O)c1ccc(cc1F)N2C(=S)N(C(=O)C2(C)C)c3ccc(C#N)c(c3)C(F)(F)F