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Substance Name: Enzalutamide [USAN:INN]
RN: 915087-33-1
UNII: 93T0T9GKNU
InChIKey: WXCXUHSOUPDCQV-UHFFFAOYSA-N
Note
- An antineoplastic agent.
NCI: An orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, enzalutamide inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance. (NCI Thesaurus)
Molecular Formula
- C21-H16-F4-N4-O2
Molecular Weight
- 464.4414
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Names and Synonyms
Name of Substance
- Enzalutamide [USAN:INN]
- MDV 3100
Synonyms
- Enzalutamide
- MDV 3100
- MDV-3100
- MDV3100
- UNII-93T0T9GKNU
- Xtandi
Systematic Name
- Benzamide, 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl)-2-fluoro-N-methyl-
Registry Numbers
CAS Registry Number
- 915087-33-1
FDA UNII
- 93T0T9GKNU
System Generated Number
- 0915087331