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Substance Name: Irloxacin [INN]
RN: 91524-15-1
UNII: 36SG77D21B
InChIKey: RZLHGQLYNZQZQQ-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C16-H13-F-N2-O3

Molecular Weight

  • 300.288
 
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Names and Synonyms

Name of Substance

  • Irloxacin [INN]
  • Pirfloxacin

Synonyms

  • 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1H-pyrrol-1-yl)-3-quinolinecarboxylic acid
  • 6-Fluoro-7-(1-pyrrolyl)-1-ethyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
  • E 3432
  • Irloxacin
  • Irloxacine
  • Irloxacine [French]
  • Irloxacino
  • Irloxacino [Spanish]
  • Irloxacinum
  • Irloxacinum [Latin]
  • NSC 610496
  • Pirfloxacin
  • UNII-36SG77D21B

Systematic Names

  • 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-pyrrol-1-yl-3-quinolinecarboxylic acid
  • 3-Quinolinecarboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1H-pyrrol-1-yl)-
  • 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1H-pyrrol-1-yl)-

Registry Numbers

CAS Registry Number

  • 91524-15-1

FDA UNII

  • 36SG77D21B

System Generated Number

  • 0091524151

Structure Descriptors

InChI

1S/C16H13FN2O3/c1-2-18-9-11(16(21)22)15(20)10-7-12(17)14(8-13(10)18)19-5-3-4-6-19/h3-9H,2H2,1H3,(H,21,22)

InChIKey

RZLHGQLYNZQZQQ-UHFFFAOYSA-N

Smiles

c1(c2c(n(CC)cc1C(O)=O)cc(n1cccc1)c(F)c2)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo intraperitoneal 2gm/kg (2000mg/kg) GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Arzneimittel-Forschung. Drug Research. Vol. 49, Pg. 448, 1999.
mouse LDLo oral 5gm/kg (5000mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LIVER: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 49, Pg. 448, 1999.
rat LD50 intraperitoneal > 2gm/kg (2000mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Arzneimittel-Forschung. Drug Research. Vol. 49, Pg. 448, 1999.
rat LD50 oral > 5gm/kg (5000mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION
Arzneimittel-Forschung. Drug Research. Vol. 49, Pg. 448, 1999.