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Substance Name: Timolol [USAN:INN:BAN]
RN: 91524-16-2
UNII: 817W3C6175
InChIKey: RFBICEPZZKOQIA-OBPBZEKASA-N

Note

  • A beta-adrenergic antagonist that is similar in action to PROPRANOLOL; the levo-isomer is more active. Timolol has been proposed as an anti-hypertensive, anti-arrhythmic, anti-angina, and anti-glaucoma agent. It is also used in the treatment of MIGRAINE DISORDERS and tremor.

Molecular Formula

  • C13-H24-N4-O3-S.1/2H2-O

Molecular Weight

  • 649.8541
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Antagonists
  • Adrenergic beta-Antagonists
  • Anti-Adrenergic (beta-Receptor)
  • Anti-Arrhythmia Agents
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Neurotransmitter Agents

Names and Synonyms

Name of Substance

  • Timolol [USAN:INN:BAN]

MeSH Heading

  • Timolol

Synonyms

  • (S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-2-propanol hemihydrate
  • 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, hemihydrate, (S)-
  • Betimol
  • Timolol
  • UNII-817W3C6175

Systematic Name

  • 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, hemihydrate, (S)-

Registry Numbers

CAS Registry Number

  • 91524-16-2

FDA UNII

  • 817W3C6175

System Generated Number

  • 0091524162

Molecular Formulas

Molecular Formula

  • C13-H24-N4-O3-S.1/2H2-O

Molecular Formula Fragments

  • C13-H24-N4-O3-S
  • COMPONENT
  • H2-O

Structure Descriptors

InChI

InChI=1S/C26H47N8O6S2.H2O/c1-25(2,3)27-13-18(35)15-38-23-21(29-41-31-23)33-8-11-40(12-9-33)20-17-37-10-7-34(20)22-24(32-42-30-22)39-16-19(36)14-28-26(4,5)6;/h18-20,27-28,35-36H,7-17H2,1-6H3;1H2/t18-,19-,20?;/m0./s1

InChIKey

RFBICEPZZKOQIA-OBPBZEKASA-N

Smiles

O.CC(C)(C)NC[C@H](O)COc1nsnc1N2CC[O](CC2)C3COCCN3c4nsnc4OC[C@@H](O)CNC(C)(C)C